Editing Coagulation (section)

===Anticoagulants===
{{Main|Antiplatelet drug|Anticoagulant}}

Anticoagulants and anti-platelet agents (together "antithrombotics") are amongst the most commonly used medications. [[Antiplatelet drug|Anti-platelet agents]] include [[aspirin]], [[dipyridamole]], [[ticlopidine]], [[clopidogrel]], [[ticagrelor]] and [[prasugrel]]; the parenteral [[glycoprotein IIb/IIIa inhibitors]] are used during [[angioplasty]]. Of the anticoagulants, [[warfarin]] (and related [[coumarin]]s) and [[heparin]] are the most commonly used. Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX, X) and protein C and protein S, whereas heparin and related compounds increase the action of antithrombin on thrombin and factor Xa. A newer class of drugs, the [[direct thrombin inhibitor]]s, is under development; some members are already in clinical use (such as [[lepirudin]], [[argatroban]], [[bivalirudin]] and [[dabigatran]]). Also in clinical use are other small molecular compounds that interfere directly with the enzymatic action of particular coagulation factors (the [[Anticoagulant#Directly acting oral anticoagulants|directly acting oral anticoagulants]]: [[dabigatran]], [[rivaroxaban]], [[apixaban]], and [[edoxaban]]).<ref name="pmid22345595">{{Cite journal |vauthors=Soff GA |date=March 2012 |title=A new generation of oral direct anticoagulants |journal=Arteriosclerosis, Thrombosis, and Vascular Biology |volume=32 |issue=3 |pages=569–74 |doi=10.1161/ATVBAHA.111.242834 |pmid=22345595 |doi-access=free}}</ref>