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GSK-3
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===Pyrimidine derivatives=== [[Pyrimidine analogue]]s are antimetabolites that interfere with nucleic acid synthesis.<ref>{{cite book |doi=10.1016/B978-0-444-59499-0.00045-3 |chapter=Cytostatic and cytotoxic drugs |title=A worldwide yearly survey of new data in adverse drug reactions and interactions |volume=34 |pages=731β747 |series=Side Effects of Drugs Annual |year=2012 | vauthors = Murphy F, Middleton M |isbn=978-0-444-59499-0 }}</ref> Some of them have been shown to fit the ATP-binding pocket of GSK-3Ξ² to lower blood glucose levels and improve some neuronal diseases.<ref>{{cite journal | vauthors = Kramer T, Schmidt B, Lo Monte F | title = Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models | journal = International Journal of Alzheimer's Disease | volume = 2012 | pages = 381029 | year = 2012 | pmid = 22888461 | pmc = 3408674 | doi = 10.1155/2012/381029 | doi-access = free }}</ref>
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