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Infant formula
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=== History === {| class="wikitable" |- ! Dates !! Events |- style="background:white" | ''' 1867 ''' | A formula containing wheat flour, cow's milk, malt flour, and potassium bicarbonate was developed.<ref name=name>Institute of Medicine (U.S.) (2004). Defining Safety for Infants. In [http://books.nap.edu/openbook.php?isbn=0309091500&page=42# “Infant Formula: Evaluating the Safety of New Ingredients”], The National Academic Press. pp. 22–42., Retrieved on November 15, 2009.</ref> |- style="background:white" | ''' 1915 ''' | A powder form of infant formula was introduced, containing cow's milk, lactose, oleo oils, and vegetable oils.<ref name=name /> |- style="background:white" | ''' 1929 ''' | Soy formula was introduced.<ref name=name /> |- style="background:white" | ''' 1935 ''' | Protein was added because it was believed cow's milk protein content was lower than human milk protein content; protein at 3.3–4.0 g/100 kcal was added.<ref name=name /> |- style="background:white" | ''' 1959 ''' | Iron fortification was introduced because a large amount of iron (~80%) is used to expand the red blood cell mass in a growing infant. Infants with birth weights between 1500 and 2500g require 2 mg/kg of iron per day. Infants with weights of less than 1500g require 4 mg/kg per day.<ref name=name /><ref>{{cite journal | vauthors = American | year = 1999 | title = Iron fortification of infant formulas | journal = Pediatrics | volume = 104 | issue = 1| pages = 119–123 | doi=10.1542/peds.104.1.119| doi-access = free }}</ref> |- style="background:white" | ''' 1962 ''' | The [[whey]]:[[casein]] ratio was made similar to human milk because producers were aware that human milk contains a higher ratio of whey protein, and cow's milk contains a higher ratio of casein.<ref name=name /> |- style="background:white" | ''' 1984 ''' | [[Taurine]] fortification was introduced because newborn infants lack the enzymes needed to convert and form taurine.<ref name=name /><ref>{{cite journal | vauthors = Heird WC | title = Taurine in neonatal nutrition--revisited | journal = Archives of Disease in Childhood. Fetal and Neonatal Edition | volume = 89 | issue = 6 | pages = F473–F474 | date = November 2004 | pmid = 15499132 | pmc = 1721777 | doi = 10.1136/adc.2004.055095 }}</ref> |- style="background:white" | ''' Late 1990 ''' | Nucleotide fortification was introduced into infant formula because nucleotides can act as growth factors and may enhance the infant immune system.<ref name=name /> |- style="background:white" | ''' Early 2000 ''' | Polyunsaturated fatty acid fortification was introduced. Polyunsaturated fatty acids, such as [[docosahexaenoic acid]] (DHA) and [[arachidonic acid]] (ARA), were added because those fatty acids play an important role in infant brain development.<ref name=name /> |}
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