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MicroRNA
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====Stroke==== According to the Center for Disease Control and Prevention, Stroke is one of the leading causes of death and long-term disability in America. 87% of the cases are [[ischemic stroke]]s, which results from blockage in the artery of the brain that carries oxygen-rich blood. The obstruction of the blood flow means the brain cannot receive necessary nutrients, such as oxygen and glucose, and remove wastes, such as carbon dioxide.<ref>{{Cite web|url=https://www.cdc.gov/stroke/facts.htm|title=Stroke Facts |date=2019-03-15|website=Centers for Disease Control and Prevention |language=en-us|access-date=2019-12-05}}</ref><ref name=":0">{{cite journal | vauthors = Rink C, Khanna S | title = MicroRNA in ischemic stroke etiology and pathology | journal = Physiological Genomics | volume = 43 | issue = 10 | pages = 521β528 | date = May 2011 | pmid = 20841499 | pmc = 3110894 | doi = 10.1152/physiolgenomics.00158.2010 }}</ref> miRNAs plays a role in posttranslational gene silencing by targeting genes in the pathogenesis of cerebral ischemia, such as the inflammatory, angiogenesis, and apoptotic pathway.<ref>{{cite journal | vauthors = Ouyang YB, Stary CM, Yang GY, Giffard R | title = microRNAs: innovative targets for cerebral ischemia and stroke | journal = Current Drug Targets | volume = 14 | issue = 1 | pages = 90β101 | date = January 2013 | pmid = 23170800 | pmc = 3673881 | doi = 10.2174/138945013804806424 }}</ref>
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