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NMDA receptor
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==== Competitive NMDA receptor antagonists ==== [[Competitive]] NMDA receptor antagonists, which were developed first, are not a good option because they compete and bind to the same site (NR2 subunit) on the receptor as the agonist, glutamate, and therefore block normal function also.<ref name="Lipton2" /><ref name="Monaghan">{{cite book| vauthors = Monaghan DT, Jane DE | veditors = Van Dongen AM |title=Biology of the NMDA Receptor|date=2009|publisher=CRC Press|location=Boca Raton, Florida|isbn=978-1-4200-4414-0|chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK5282/|chapter=Pharmacology of NMDA Receptors| series = Frontiers in Neuroscience |pmid=21204415}}</ref> They will block healthy areas of the brain prior to having an impact on pathological areas, because healthy areas contain lower levels of [[agonist]] than pathological areas. These antagonists can be displaced from the receptor by high concentration of glutamate which can exist under excitotoxic circumstances.<ref name="Chen" />
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