Editing Spatial memory (section)

===NEIL1===

Endonuclease VIII-like 1 ([[NEIL1]]) is a [[DNA repair]] enzyme that is widely expressed throughout the [[brain]].  NEIL1 is a [[DNA glycosylase]] that initiates the first step in [[base excision repair]] by cleaving bases damaged by reactive oxygen species and then introducing a DNA strand break via an associated [[lyase]] reaction.  This enzyme recognizes and removes [[DNA oxidation|oxidized DNA bases]] including [[Formamidopyrimidine DNA glycosylase|formamidopyrimidine]], [[thymine glycol]], [[5-hydroxyuracil]] and [[5-hydroxycytosine]].  NEIL1 promotes short-term spatial memory retention.<ref name="pmid22927410">{{cite journal |vauthors=Canugovi C, Yoon JS, Feldman NH, Croteau DL, Mattson MP, Bohr VA |title=Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=109 |issue=37 |pages=14948–53 |date=September 2012 |pmid=22927410 |pmc=3443144 |doi=10.1073/pnas.1204156109 |bibcode=2012PNAS..10914948C |doi-access=free }}</ref>  Mice lacking NEIL1 have impaired short-term spatial memory retention in a water maze test.<ref name="pmid22927410" />