Editing Reptile (section)

===Longevity===

Giant [[tortoise]]s are among the longest-lived vertebrate animals (over 100 years by some estimates) and have been used as a model for studying [[longevity]].<ref name="Quesada2019">Quesada V, Freitas-Rodríguez S, Miller J, Pérez-Silva JG, Jiang ZF, Tapia W, Santiago-Fernández O, Campos-Iglesias D, Kuderna LFK, Quinzin M, Álvarez MG, Carrero D, Beheregaray LB, Gibbs JP, Chiari Y, Glaberman S, Ciofi C, Araujo-Voces M, Mayoral P, Arango JR, Tamargo-Gómez I, Roiz-Valle D, Pascual-Torner M, Evans BR, Edwards DL, Garrick RC, Russello MA, Poulakakis N, Gaughran SJ, Rueda DO, Bretones G, Marquès-Bonet T, White KP, Caccone A, López-Otín C. Giant tortoise genomes provide insights into longevity and age-related disease. Nat Ecol Evol. 2019 Jan;3(1):87-95. doi: 10.1038/s41559-018-0733-x. Epub 2018 Dec 3. PMID 30510174; PMCID: PMC6314442</ref> DNA analysis of the [[genome]]s of [[Lonesome George]], the iconic last member of ''[[Pinta Island tortoise|Chelonoidis abingdonii]]'', and the [[Aldabra giant tortoise]] ''Aldabrachelys gigantea'' led to the detection of lineage-specific variants affecting [[DNA repair]] genes that might contribute to our understanding of increased lifespan.<ref name = Quesada2019/>