Editing ABC transporter (section)

==== ABCC ====
Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions.<ref name="Chen_2011">{{cite journal | vauthors = Chen ZS, Tiwari AK | title = Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases | journal = The FEBS Journal | volume = 278 | issue = 18 | pages = 3226–45 | date = Sep 2011 | pmid = 21740521 | pmc = 3168698 | doi = 10.1111/j.1742-4658.2011.08235.x }}</ref> They are known to be involved in ion transport, toxin secretion, and signal transduction.<ref name="Dean_2001"/> Of the nine MRP proteins, four of them, MRP4, 5, 8, 9, (ABCC4, 5, 11, and 12),  have a typical ABC structure with four domains, comprising two membrane spanning domains, with each spanning domain followed by a nucleotide binding domain.   These are referred to as short MRPs. The remaining 5 MRP's (MRP1, 2, 6, 7) (ABCC1, 2, 3, 6 and 10) are known as long MRPs and feature an additional fifth domain at their [[N terminus]].<ref name="Chen_2011"/>

[[Cystic fibrosis transmembrane conductance regulator|CFTR]], the transporter involved in the disease [[cystic fibrosis]], is also considered part of this subfamily. Cystic fibrosis occurs upon mutation and loss of function of CFTR.<ref name="Dean_2001"/>

The [[sulfonylurea receptor|sulfonylurea receptors (SUR)]], involved in insulin secretion, neuronal function, and muscle function, are also part of this family of proteins. Mutations in SUR proteins are a potential cause of [[Neonatal diabetes mellitus]]. SUR is also the binding site for drugs such as [[sulfonylureas]] and potassium-channel openers activators such as [[diazoxide]].