Editing Functional genomics (section)

=== The Genotype-Tissue Expression (GTEx) project ===
[[File:Nature24277-f1.jpg|thumb|Samples used and eQTLs discovered in GTEx v6]]
The GTEx project is a human genetics project aimed at understanding the role of genetic variation in shaping variation in the transcriptome across tissues. The project has collected a variety of tissue samples (> 50 different tissues) from more than 700 post-mortem donors. This has resulted in the collection of >11,000 samples. GTEx has helped understand the tissue-sharing and tissue-specificity of [[eQTL]]s.<ref>{{cite journal | vauthors = Battle A, Brown CD, Engelhardt BE, Montgomery SB | collaboration = GTEx Consortium | title = Genetic effects on gene expression across human tissues | journal = Nature | volume = 550 | issue = 7675 | pages = 204–213 | date = October 2017 | pmid = 29022597 | pmc = 5776756 | doi = 10.1038/nature24277 | bibcode = 2017Natur.550..204A }}</ref> The genomic resource was developed to "enrich our understanding of how differences in our DNA sequence contribute to health and disease."<ref>{{Cite web|url=https://commonfund.nih.gov/highlights2017|title=GTEx Creates a Reference Data Set to Study Genetic Changes and Gene Expression|access-date=2022-01-13| publisher = U.S. National Institutes of Health | work = Office of Strategic Coordination - The Common Fund|date=8 February 2018 }}</ref>