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=== April–June === * [[April 7]] ** [[Ferdinand Magellan]] arrives at [[Cebu]].<ref>{{cite book |last1=Aluit |first1=Alphonso J. |title=The Philippines: Comprehensive, Authoritative, Up-to-date |date=1990 |publisher=Solar Publishing Company |isbn=978-971-17-0637-1 |page=305 |url=https://books.google.com/books?id=GWZxAAAAMAAJ&q=%227%20april%201521%22 |access-date=25 July 2023 |language=en}}</ref> ** [[Martin Luther]] preaches an inflammatory sermon to students at [[Erfurt]], while on his way to Worms.<ref>{{cite book |last1=Old |first1=Hughes Oliphant |title=The Reading and Preaching of the Scriptures in the Worship of the Christian Church, Volume 4: The Age of the Reformation |date=2 May 2002 |publisher=Wm. B. Eerdmans Publishing |isbn=978-0-8028-4775-1 |page=7 |url=https://books.google.com/books?id=jhw1eKcDtHYC&q=%227+april%22 |access-date=25 July 2023 |language=en}}</ref> * [[April 16]]–[[April 18|18]] – [[Martin Luther]] is examined before [[Charles V, Holy Roman Emperor|Emperor Charles V]] and the [[Diet of Worms]], where he refuses to recant his writings and allegedly proclaims, "Here I stand", regarding his belief in the Bible alone, as the standard of Christian doctrine. * [[April 23]] – [[Revolt of the Comuneros]] – [[Battle of Villalar]]: [[Crown of Castile|Castilian]] royalists defeat the rebels.<ref name="REV">{{cite book |last1=Haliczer |first1=Stephen |title=The Comuneros of Castile : the forging of a revolution, 1475-1521 |date=1981 |publisher=University of Wisconsin Press |location=Madison |isbn=978-0-299-08500-1 |page=204 |url=https://archive.org/details/comunerosofcasti0000hali/page/204/mode/2up?q=%22april+23%22 |access-date=25 July 2023}}</ref> [[Juan López de Padilla]], [[Francisco Maldonado]], and [[Juan Bravo]] are executed the following day as the leaders of the rebels. * [[April 26]] – [[Martin Luther]] leaves [[Worms, Germany|Worms]] and disappears for around a year<ref>{{cite web |title=HISTORY OF THE CHRISTIAN CHURCH* |url=https://www.ccel.org/s/schaff/history/7_ch04.htm |website=www.ccel.org |access-date=25 July 2023}}</ref> – he is rumored to be murdered, but is actually in hiding at the [[Wartburg]] castle.<ref>{{cite book |last1=Saxl |first1=Fritz |title=A heritage of images: a selection of lectures |date=1970 |publisher=Penguin Books |location=Harmondsworth |isbn=978-0-14-055088-7 |page=112 |url=https://archive.org/details/heritageofimages0000saxl/page/112/mode/2up?q=%2226+april%22 |access-date=25 July 2023}}</ref> * [[April 27]] – [[Battle of Mactan]]: [[Ferdinand Magellan]] is killed in the [[Philippines]] when he confronts [[Lapulapu]], the chief of the island.<ref>{{cite journal |last1=Martínez-García |first1=Ángeles |last2=Gómez-Aguilar |first2=Antonio |title=Magallanes: Building a Hero |journal=Revista Latina de Comunicación Socia |date=2019 |volume=74 |pages=618–636 |url=https://www.proquest.com/openview/4e2cd8eca7b7e13b7c9b0034f79870a4/1?pq-origsite=gscholar&cbl=236244 |access-date=25 July 2023 |language=en}}</ref> * [[April]] or [[May]] – [[Battle of Tunmen]] in [[Tuen Mun]] (present-day Hong Kong): The Ming Dynasty navy defeats the Portuguese navy<ref>{{cite book |last1=Hao |first1=Zhidong |title=Macau History and Society |date=1 January 2011 |publisher=Hong Kong University Press |isbn=978-988-8028-54-2 |pages=11–12 |url=https://books.google.com/books?id=LP9q1dzVRYQC&q=%22april%22+tunmen |access-date=25 July 2023 }}</ref> (arguably the first Sino-European battle in world history). * [[May 17]] – [[Edward Stafford, 3rd Duke of Buckingham]], is executed for [[treason]] in [[Tower Hill]].<ref name="ES">{{cite journal |last1=Harris |first1=Barbara |title=The Trial of the Third Duke of Buckingham-A Revisionist View |journal=The American Journal of Legal History |date=1976 |volume=20 |issue=1 |pages=15–26 |doi=10.2307/844847 |jstor=844847 |url=https://www.jstor.org/stable/844847 |access-date=25 July 2023 |issn=0002-9319|url-access=subscription }}</ref> * [[May 20]] – At the [[Battle of Pampeluna]] in [[Italy]], and alliance of forces from [[France|French]] and the [[Kingdom of Navarre]] forces defeat those of [[Spain]].<ref>{{cite book|title=Studies|url=https://books.google.com/books?id=JTrhAAAAMAAJ|year=1985|publisher=Studies|page=230}}</ref> * [[May 25]] – The [[Diet of Worms]] ends when [[Charles V, Holy Roman Emperor]] issues the [[Edict of Worms]], declaring [[Martin Luther]] an outlaw and banning his literature.<ref>{{cite book |last1=Darian-Smith |first1=Eve |title=Religion, Race, Rights: Landmarks in the History of Modern Anglo-American Law |date=20 May 2010 |publisher=Bloomsbury Academic |isbn=978-1-84113-729-2 |page=28 |url=https://books.google.com/books?id=xt4pAQAAMAAJ&q=%20outlaw |access-date=26 July 2023 |language=en}}</ref> * [[May 27]] – After death of his cousin, [[Jiajing Emperor|Jiajing]], Prince Zhu Houcong became the new [[Ming dynasty]] Emperor of China, taking the imperial name of the [[Jiajing Emperor|Emperor Jiajing]] becomes the new.<ref>{{cite book |last1=Geiss |first1=James |title=The Cambridge History of China|volume=7: The Ming Dynasty, 1368–1644 |date=1988 |publisher=Cambridge University Press |isbn=978-0-521-24332-2 |pages=440–510 |url=https://www.cambridge.org/core/books/abs/cambridge-history-of-china/chiaching-reign-15221566/60E9B518B7E3782006F9CC5DF0C4932D |access-date=26 July 2023 |chapter=The Chia-ching reign, 1522–1566}}</ref> * [[June 25]] – [[Suleiman the Magnificent]] begins the [[Siege of Belgrade (1521)|siege of Belgrade]]. * [[June 29]] or [[June 30|30]] – The oldest surviving dateable document written primarily in the [[Romanian language]]: [[Neacșu's letter]], written by a trader from [[Câmpulung]], to Johannes Benkner, the mayor of [[Brașov]], warning that the [[Ottoman Empire]] is preparing its troops to cross into [[Wallachia]] and [[Transylvania]]; the script used is [[Romanian Cyrillic alphabet|Romanian Cyrillic]]. * [[June 30]] – [[Battle of Esquiroz]]: [[Kingdom of France|French]] forces under [[André de Foix]], fighting for the exiled King of [[Navarre]] [[Henry II of Navarre|Henri d'Albret]], are defeated by the [[Spanish Empire|Spanish]], and forced to abandon their attempt to recover Henri's kingdom.<ref>{{cite book |last1=Soraluce |first1=Nicolás de |title=Historia de la m. n. y m. l. Provincia de Guipúzcoa |date=1864 |publisher=Joaquin Bernat |location=Madrid |page=241 |url=https://books.google.com/books?id=hl1BAAAAcAAJ&dq=Batalla+de+No%C3%A1in+Enrique+II+%2230+de+junio+de+1521%22&pg=PA241 |access-date=26 July 2023 |language=es}}</ref>
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