Editing Alternative complement pathway (section)

==Role in disease==
Dysregulation of the complement system has been implicated in several diseases and pathologies, including [[atypical hemolytic uremic syndrome]] in which kidney function is compromised. [[Age related macular degeneration]] (AMD) is now believed to be caused, at least in part, by complement overactivation in retinal [[Tissue (biology)|tissue]]s.<ref name=":0">{{Cite journal|last1=Tzoumas|first1=Nikolaos|last2=Hallam|first2=Dean|last3=Harris|first3=Claire L.|last4=Lako|first4=Majlinda|last5=Kavanagh|first5=David|last6=Steel|first6=David H.W.|date=November 2020|title=Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants|url=https://doi.org/10.1016/j.survophthal.2020.10.008|journal=Survey of Ophthalmology|volume=66|issue=2|pages=378–401|doi=10.1016/j.survophthal.2020.10.008|pmid=33157112|s2cid=226274874|issn=0039-6257|url-access=subscription}}</ref>  Alternative pathway activation also plays a significant role in complement-mediated renal disorders such as atypical hemolytic uremic syndrome, [[C3 glomerulopathy]], and [[C3 glomerulonephritis]] (Dense Deposit Disease or MPGN Type II).<ref name=":0" />