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Benzo(a)pyrene
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== History == In the 18th century, young British [[chimney sweep]]s who climbed into chimneys suffered from [[chimney sweeps' carcinoma]], a scrotal cancer peculiar to their profession, and this was connected to the effects of [[soot]] in 1775,<ref>{{cite book |last1=Pott |first1=Percivall |title=Chirurgical Observations β¦ |date=1775 |publisher=L. Hawes, W. Clarke, and R. Collins |location=London, England |pages=63β68 |url=https://books.google.com/books?id=15htmgEACAAJ&pg=PA63}} From p. 67: "The disease, in these people [i.e., chimney sweeps], seems to derive its origin from a lodgment of soot in the rugae of the scrotum, β¦ "</ref> in the first work of [[occupational cancer]] epidemiology and also the first connection of any [[chemical mixture]] to cancer formation. Frequent [[skin cancer]]s were noted among fuel industry workers in the 19th century. In 1933, B''a''P was determined to be the compound responsible for these cases, and its carcinogenicity was demonstrated when skin tumors occurred in laboratory animals repeatedly painted with coal tar.<ref>{{cite journal | last1 = Cook | first1 = J. W. | last2 = Hewett | first2 = C. L. | last3 = Hieger | first3 = I. | year = 1933 | title = The isolation of a cancer producing Hydrocarbon from coal tar | url = https://pubs.rsc.org/en/Content/ArticleLanding/1933/JR/jr9330000395 | journal = J. Chem. Soc. | volume = 1933 | pages = 395β405 | doi = 10.1039/jr9330000395 | url-access = subscription }}</ref> B''a''P has since been identified as a prime carcinogen in cigarette smoke.<ref>{{cite journal | last1 = Hecht | first1 = SS | year = 1999 | title = Tobacco smoke carcinogens and lung cancer | journal = J Natl Cancer Inst | volume = 91 | issue = 14| pages = 1194β210 | pmid = 10413421 | doi = 10.1093/jnci/91.14.1194 | doi-access = free }}</ref>
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