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Blastocoel
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=== Damage to blastocoel === The blastocoel can be damaged and abolished if the adhesion between blastomeres, provided by cell adhesion molecules like EP-cadherin, is destroyed as mRNA by [[oligonucleotide]]s. If the mRNA is destroyed, then thereβs no EP-cadherin, little to no blastomere adhesion and the blastocoel is non-existent.<ref name="Heasman"/> During the next stage of embryonic development, amphibian [[gastrulation]], the blastocoel is displaced by the formation of the [[archenteron]], during mid-gastrulation. At the end of gastrulation, the blastocoel has been obliterated.<ref name="Purcell">{{cite journal |last1=Purcell |first1=SM |last2=Keller |first2=R |title=A different type of amphibian mesoderm morphogenesis in Ceratophrys ornata. |journal=Development |date=January 1993 |volume=117 |issue=1 |pages=307β17 |doi=10.1242/dev.117.1.307 |pmid=8223254}}</ref>
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