Editing Breast reduction (section)

===Cause===
Large breasts are usually developed during [[thelarche]] (the pubertal breast-development stage), but they can also develop postpartum, after gaining weight, at [[menopause]], and at any age. Macromastia usually develops in consequence to the [[hypertrophy]] (overdevelopment) of [[Adipose tissue|adipose fat]], rather than to milk-gland hypertrophy. Moreover, many are [[Genetics|genetically]] predisposed to developing large breasts, the size and weight of which are often increased, either by [[pregnancy]], by weight gain, or by both conditions; there also exist [[Iatrogenesis|iatrogenic]] (physician-caused) conditions such as post–[[mastectomy]] and post–[[lumpectomy]] asymmetry. Nonetheless, it is statistically rare for a young person to experience juvenile mammary hypertrophy that results in massive, oversized breasts, and recurrent [[Hypertrophy of breast|breast hypertrophy]].{{citation needed|date=July 2015}}

The abnormal enlargement of the breast tissues to a volume in excess of the normal bust-to-body proportions can be caused either by the overdevelopment of the [[Lactiferous duct|milk glands]] or of the [[adipose tissue]], or by a combination of both occurrences of hypertrophy. The resultant breast-volume increases can range from the mild (<300 gm) to the moderate (ca. 300–800 gm) to the severe (>800 gm). Macromastia can be manifested either as a unilateral condition or as a bilateral condition (single-breasted enlargement or double-breasted enlargement) that can occur in combination with sagging, [[Ptosis (breasts)|breast ptosis]] that is determined by the degree to which the nipple has descended below the inframammary fold (IMF).<ref name="Grippaudo">{{EMedicine|article|1276259|Liposuction Only Breast Reduction}}</ref>