Editing C-terminus (section)

===C-terminal retention signals===
While the [[N-terminus]] of a protein often contains [[Protein targeting|targeting signals]], the C-terminus can contain retention signals for protein sorting. The most common [[ER retention]] signal is the amino acid sequence [[KDEL (amino acid sequence)|-KDEL]] ([[lysine|Lys]]-[[Aspartic acid|Asp]]-[[Glutamic acid|Glu]]-[[Leucine|Leu]]) or [[HDEL (amino acid sequence)|-HDEL]] ([[Histidine|His]]-Asp-Glu-Leu) at the C-terminus.  This keeps the protein in the [[endoplasmic reticulum]] and prevents it from entering the [[secretory pathway]].