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COPII
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==Regulation== The signal(s) that triggers Sec12 to initiate COPII assembly remains unclear, though some regulators of coat formation are now known.<ref name=Lodish14>{{cite book|chapter=14 - Vesicular Traffic, Secretion, and Endocytosis |title=Molecular Cell Biology |edition=8 |pages=639β641 |vauthors=Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A, Martin KC |publisher=W. H Freeman |location=New York |date=2016 |isbn=9781464183393}}</ref> The frequency of COPII formation is regulated in part by Sec16A and [[Tango1]] proteins, likely by concentrating Sec12 in a given location, so it can more efficiently activate Sar1.<ref name=Peotter2019/>
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