Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Calcium channel
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
===Ligand-gated=== *''receptor-operated calcium channels'' {| class="wikitable" | style="text-align:center" | '''Type''' || '''Gated by''' || '''Gene''' || '''Location''' || '''Function''' |- | [[Inositol triphosphate receptor|IP<sub>3</sub> receptor]] || [[inositol triphosphate|IP<sub>3</sub>]] || ITPR1, ITPR2, ITPR3 || [[endoplasmic reticulum|ER]]/[[sarcoplasmic reticulum|SR]] || Releases calcium from ER/SR in response to IP<sub>3</sub> by e.g. [[GPCR]]s<ref name=Rang53>{{cite book | vauthors = Rang HP |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |isbn=978-0-443-07145-4 |page = 54 }}</ref> |- | [[Ryanodine receptor]] || [[dihydropyridine receptor]]s in [[T-tubule]]s and increased intracellular calcium (Calcium Induced Calcium Release - CICR) || RYR1, RYR2, RYR3 || [[endoplasmic reticulum|ER]]/[[sarcoplasmic reticulum|SR]] || [[Calcium-induced calcium release]] in [[myocyte]]s<ref name=Rang53/> |- | [[Two-pore channel]] ||Nicotinic acid adenine dinucleotide phosphate ([[Nicotinic acid adenine dinucleotide phosphate|NAADP]])||TPCN1, TPCN2||endosomal/lysosomal membranes||NAADP-activated calcium transport across endosomal/lysosomal membranes<ref>{{Cite web|url=https://www.uniprot.org/uniprot/Q9ULQ1|title=TPCN1 - Two pore calcium channel protein 1 - Homo sapiens (Human) - TPCN1 gene & protein|website=www.uniprot.org|language=en|access-date=2017-12-11}}</ref> |- | ''store-operated channels''<ref>{{Cite journal |last1=Prakriya |first1=Murali |last2=Lewis |first2=Richard S. |date=Oct 2015 |title=Store-Operated Calcium Channels |journal=Physiological Reviews |language=en |volume=95 |issue=4 |pages=1383–1436 |doi=10.1152/physrev.00020.2014 |issn=0031-9333 |pmc=4600950 |pmid=26400989}}</ref>|| indirectly by [[endoplasmic reticulum|ER]]/[[sarcoplasmic reticulum|SR]] depletion of calcium<ref name="Rang53" />|| ORAI1, ORAI2, ORAI3 || [[plasma membrane]] || Provides calcium signaling to the cytoplasm<ref>{{cite journal | vauthors = Putney JW, Steinckwich-Besançon N, Numaga-Tomita T, Davis FM, Desai PN, D'Agostin DM, Wu S, Bird GS | display-authors = 6 | title = The functions of store-operated calcium channels | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research| volume = 1864 | issue = 6 | pages = 900–906 | date = June 2017 | pmid = 27913208 | pmc = 5420336 | doi = 10.1016/j.bbamcr.2016.11.028 }}</ref> |- |}
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)