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Cannabinoid receptor
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=== CB<sub>1</sub> === {{Main|Cannabinoid receptor type 1}} Cannabinoid receptor type 1 (CB<sub>1</sub>) receptors are thought to be one of the most widely [[Gene expression|expressed]] G<sub>Ξ±i</sub> protein-coupled receptors in the brain. One mechanism through which they function is endocannabinoid-mediated [[depolarization-induced suppression of inhibition]], a very common form of [[retrograde signaling]], in which the depolarization of a single neuron induces a reduction in [[GABA]]-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB<sub>1</sub> receptors in the pre-synaptic neuron and cause a reduction in GABA release due to limited presynaptic calcium ions entry.{{medcn|date=December 2017}} They are also found in other parts of the body. For instance, in the liver, activation of the CB<sub>1</sub> receptor is known to increase de novo [[lipogenesis]].<ref name="pmid15864349"/>
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