Editing Cell-mediated immunity (section)

==Overview==

CD4<sup>+</sup> [[T-helper cell]]s may be differentiated into two main categories:<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity.">{{cite journal |last1=Annunziato |first1=F |last2=Romagnani |first2=C |last3=Romagnani |first3=S |title=The 3 major types of innate and adaptive cell-mediated effector immunity. |journal=The Journal of Allergy and Clinical Immunology |date=March 2015 |volume=135 |issue=3 |pages=626–35 |doi=10.1016/j.jaci.2014.11.001 |pmid=25528359|doi-access=free }}</ref>
# T<sub>H</sub>1 cells which produce [[interferon gamma]] and [[lymphotoxin alpha]],
# T<sub>H</sub>2 cells which produce [[Interleukin 4|IL-4]], [[Interleukin 5|IL-5]], and [[Interleukin 13|IL-13]].

A third category called [[T helper 17 cell]]s (T<sub>H</sub>17) were also discovered which are named after their secretion of [[Interleukin 17]].

CD8<sup>+</sup> [[cytotoxic T-cell]]s may also be categorized as:<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity." />
# T<sub>c</sub>1 cells,
# T<sub>c</sub>2 cells.

Similarly to CD4<sup>+</sup> T<sub>H</sub> cells, a third category called T<sub>C</sub>17 were discovered that also secrete IL-17.

As for the [[Innate lymphoid cell|ILCs]], they<sup>''[Clarification needed.]''</sup> may be classified into three main categories<ref name="The 3 major types of innate and adaptive cell-mediated effector immunity." />
# [[ILC1]] which secrete type 1 cytokines,
# [[ILC2]] which secrete type 2 cytokines,
# [[ILC3]] which secrete type 17 cytokines.