Editing Chromosomal inversion (section)

== Effects on recombination ==
When an inversion carrying chromosome is paired with a non-inverted homologous chromosome (Inversion heterozygotes) during [[meiosis]], they fail to synapse properly and inversion loops are formed. A [[Chromosomal crossover|crossing-over]] within the loop can produce unbalanced [[Gamete|gametes]]. In a paracentric inversion, [[Genetic recombination|recombination]] results in one dicentric [[chromatid]] and one acentric chromatid. During [[Anaphase]], both recombinants are faced with problems. The acentric chromatid is pulled to one pole or the other, and the dicentric recombinant generates dicentric bridges as it is pulled in two directions.<ref name=":3">{{Cite web |title=Concepts of Genetics |url=https://www.pearson.com/en-us/subject-catalog/p/concepts-of-genetics/P200000006954/9780135564776 |access-date=2022-12-05 |website=www.pearson.com |archive-date=2022-12-05 |archive-url=https://web.archive.org/web/20221205012906/https://www.pearson.com/en-us/subject-catalog/p/concepts-of-genetics/P200000006954/9780135564776 |url-status=live }}</ref>

In a pericentric inversion, similar imbalanced chromosomes are produced. The recombinant chromosomes resulting from these crosses include [[Deletion (genetics)|deletions]] and [[Gene duplication|duplications]]. The offspring produced by such gametes are mostly inviable, and therefore, recombination is indirectly suppressed within inverted regions.<ref name=":3" />