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Classical complement pathway
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=== Formation of C4b convertase === The binding of C1q with pathogen surface or antigen-antibody immune complex leads to conformational changes and the activation of the serine protease C1r. The activated C1r then cleaves and activates the serine protease C1s.<ref name="Complement history" /><ref name="C1q" /> Activated C1s cleaves [[Complement component 4|C4]] into C4a and C4b.
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