Editing Clonal anergy (section)

==Clinical significance==
Anergy may be taken advantage of for therapeutic uses. The immune response to grafting of transplanted organs and tissues could be minimized without weakening the entire immune system— a side effect of immunosuppressive drugs like [[cyclosporine]]. Anergy may also be used to induce activated lymphocytes to become unresponsive with autoimmune diseases like [[diabetes mellitus]], [[multiple sclerosis]] and [[rheumatoid arthritis]].<ref name=Schwartz/> Likewise, preventing anergy in response to a tumoral growth may help in anti-tumor responses.<ref name="Saibil et al">{{cite journal | vauthors = Saibil SD, Deenick EK, Ohashi PS | title = The sound of silence: modulating anergy in T lymphocytes | journal = Current Opinion in Immunology | volume = 19 | issue = 6 | pages = 658–664 | date = December 2007 | pmid = 17949964 | doi = 10.1016/j.coi.2007.08.005 }}</ref> It might also be used for immunotherapeutic treatment of allergies.<ref>{{cite journal | vauthors = Rolland J, O'Hehir R | title = Immunotherapy of allergy: anergy, deletion, and immune deviation | journal = Current Opinion in Immunology | volume = 10 | issue = 6 | pages = 640–645 | date = December 1998 | pmid = 9914222 | doi = 10.1016/s0952-7915(98)80082-4 }}</ref>