Editing Contraceptive patch (section)

===Interactions and contraindications===
Contraceptive effectiveness of the patch or any other hormonal contraceptive may be reduced significantly if administered alongside various [[antibiotics]], [[antifungals]], [[anticonvulsants]], or other drugs that increase metabolism of contraceptive steroids.{{medical citation needed|date=February 2020}}

However, despite the interactions with many other antibiotics, a clinical pharmacokinetic drug interaction study showed that oral administration of [[tetracycline]] HCl 500&nbsp;mg for three days prior to and seven days during use of Ortho Evra "did not reduce effectiveness of Ortho Evra."  This is a significant factor in the common decision to administer tetracycline-derived antibiotics following an [[abortion]] (preventatively to fight potential infection) when synthetic hormone contraceptives are to be used afterwards.{{medical citation needed|date=July 2007}}

Drugs containing [[St. John's Wort|St. John's wort]] are also known to affect the effectiveness of hormonal contraceptives.{{medical citation needed|date=February 2020}}

It has also been found that the patch is less effective in women who weigh more than 198 pounds (90&nbsp;kg).

The contraceptive patch and other combination hormonal contraceptives are contraindicated in women older than 35 years who smoke cigarettes.<ref name="Xulane label" />

The contraceptive patch is contraindicated for use in women with a BMI ≥ 30{{nbsp}}kg/m<sup>2</sup>.<ref name="Xulane label" />