Editing Cyclin-dependent kinase complex (section)

=== Glycine-rich region ===
The [[glycine]]-rich loop (Gly-rich loop) as seen in residues 12-16 in CDK2 encodes a conserved GXGXXG motif across both yeast and animal models. The regulatory region is subject to differential phosphorylation at non-glycine residues within this motif, making this site subject to [[Wee1]] and/or [[MYT1|Myt1]] inhibitory kinase phosphorylation and [[Cdc25]] de-phosphorylation in mammals. This reversible phosphorylation at the Gly-rich loop in CDK2 occurs at Y15, where activity has been further studied. Study of this residue has shown that phosphorylation promotes a conformational change that prevents ATP and substrate binding by steric interference with these necessary binding sites in the activation loop of the CDK-cyclin complexes. This activity is aided by the notable flexibility that the Gly-rich loop has within the structure of most CDK allowing for its rotation toward the activation loop to have a significant effect on reducing substrate affinity without major changes in the overall CDK-cyclin complex structure.<ref name=":0" /><ref>Malumbres: Cyclin-dependent kinases. ''Genome Biology,'' 2014, 15:22, {{doi|10.1186/gb4184}}</ref>