Editing David Baltimore (section)

===Independent investigator===
In February 1965, Baltimore was recruited by [[Renato Dulbecco]] to the newly established [[Salk Institute for Biological Studies]] in La Jolla as an independent research associate.<ref name=":2">{{Cite web|last=The American Association of Immunologists, Inc.|date=n.d.|title=David Baltimore, Ph.D.|url=https://www.aai.org/About/History/Notable-Members/Nobel-Laureates/DavidBaltimore|url-status=live|access-date=28 February 2021|website=The American Association of Immunologists, Inc.|archive-url=https://web.archive.org/web/20180418161308/http://www.aai.org/About/History/Notable-Members/Nobel-Laureates/DavidBaltimore |archive-date=April 18, 2018 }}</ref> There he investigated [[poliovirus]] RNA replication and began a long and storied career of mentoring other scientists' early careers including Marc Girard, and Michael Jacobson.<ref name=":1" /><ref>{{Cite web|title=Madridge Publishers|url=https://madridge.org/|access-date=2021-02-28|website=madridge.org|language=en-us}}</ref> They discovered the mechanism of [[proteolytic cleavage]] of viral polyprotein precursors,<ref name=NobelLecture>{{cite web| vauthors = Baltimore D |title=Viruses, Polymerases and Cancer:Nobel Lecture, December 12, 1975|url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/1975/baltimore-lecture.pdf|website=Nobel Prize.org}}</ref> pointing to the importance of [[proteolysis|proteolytic processing]] in the synthesis of eukaryotic proteins.<ref name=OralHistoryCHF>{{cite book | vauthors = Schlesinger S |title=David Baltimore, Transcript of Three Interviews Conducted by Sondra Schlesinger at New York City, New York; Cambridge, Massachusetts; and Boston, Massachusetts on 7 February 1994, 13 April 1995, 29 April 1995 |date=April 29, 1995 |url=https://oh.sciencehistory.org/sites/default/files/baltimore_d_0198_suppl.pdf|place=Philadelphia, PA|publisher=[[Chemical Heritage Foundation]] }}</ref><ref name=Bhaskaran>{{cite news|vauthors=Bhaskaran H|title=Alice Huang: Keeping Science and Life in Focus|url=http://www.typecraft.com/caltechnewsB/011999a/index.html|access-date=May 23, 2015|work=Caltech news|volume=33|issue=1|date=1999|archive-date=May 23, 2015|archive-url=https://web.archive.org/web/20150523170655/http://www.typecraft.com/caltechnewsB/011999a/index.html|url-status=dead}}</ref> He also met his future wife, Alice Huang, who began working with Baltimore at [[Salk Institute for Biological Studies|Salk]] in 1967.<ref name=Bhaskaran/><ref name="Huang, Caltech">{{cite web|url=http://www.baltimoreassociates.com/alice_huang.html|title=Dr. Alice S. Huang, Ph.D.|publisher=Baltimore Associates, [[California Institute of Technology]]}}</ref> He and Alice together carried out key experiments on defective interfering particles and viral pseudo types. During this work, he made a key discovery that polio produced its viral proteins as a single large polyprotein that was subsequently processed into individual functional peptides.<ref name=OralHistoryCHF/><ref name=Bhaskaran/>