Editing Domperidone (section)

===Gastroparesis===
[[Gastroparesis]] is a medical condition characterised by delayed emptying of the stomach when there is <u>no</u> mechanical [[gastric outlet obstruction]]. Its cause is most commonly [[idiopathic]], a [[diabetes|diabetic]] complication or a result of abdominal surgery. The condition causes nausea, vomiting, [[postprandial|fullness after eating]], early satiety (feeling full before the meal is finished), abdominal pain, and bloating. Domperidone can be used to increase the transit of food through the stomach by increasing [[gastrointestinal]] [[peristalsis]] and hence to treat gastroparesis.<ref name="mechanismforantiemetic"/><ref name="pmid10332535" /> It may be useful in idiopathic and diabetic gastroparesis.<ref>{{cite journal | vauthors = Stevens JE, Jones KL, Rayner CK, Horowitz M | title = Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives | journal = Expert Opinion on Pharmacotherapy | volume = 14 | issue = 9 | pages = 1171–1186 | date = June 2013 | pmid = 23663133 | doi = 10.1517/14656566.2013.795948 | s2cid = 23526883 }}</ref><ref name="pmid9663360">{{cite journal | vauthors = Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A | title = Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group | journal = Clinical Therapeutics | volume = 20 | issue = 3 | pages = 438–453 | year = 1998 | pmid = 9663360 | doi = 10.1016/S0149-2918(98)80054-4 }}</ref> However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate well with relief of symptoms.<ref>{{cite journal | vauthors = Janssen P, Harris MS, Jones M, Masaoka T, Farré R, Törnblom H, Van Oudenhove L, Simrén M, Tack J | title = The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis | journal = The American Journal of Gastroenterology | volume = 108 | issue = 9 | pages = 1382–1391 | date = September 2013 | pmid = 24005344 | doi = 10.1038/ajg.2013.118 | s2cid = 32835351 }}</ref>