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Endocrine disruptor
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==Effects on intrinsic hormones== [[Toxicology]] research shows that some endocrine disruptors target the specific hormone trait that allows one hormone to regulate the production or degradation of intrinsic hormones.<ref>{{cite book | vauthors = Harold Z | date = 2011 | title = Human Toxicology of Chemical Mixtures | edition = 2nd | publisher = Elsevier | isbn = 978-1-4377-3463-8 }}</ref><ref>{{cite book | vauthors = Yu MH, Tsunoda H, Tsunoda M | date = 2016 | title = Environmental Toxicology: Biological and Health Effects of Pollutants | edition = Third | publisher = CRC Press | isbn = 978-1-4398-4038-2 }}</ref> As endocrine disruptors have the potential to mimic or antagonize natural hormones, these chemicals can exert their effects by acting through interaction with [[nuclear receptor]]s, the [[aryl hydrocarbon receptor]] or membrane bound receptors.<ref>{{cite journal | vauthors = Toporova L, Balaguer P | title = Nuclear receptors are the major targets of endocrine disrupting chemicals | journal = Molecular and Cellular Endocrinology | volume = 502 | pages = 110665 | date = February 2020 | pmid = 31760044 | doi = 10.1016/j.mce.2019.110665 | s2cid = 209493576 | url = https://hal.archives-ouvertes.fr/hal-03488727/file/S0303720719303673.pdf }}</ref><ref>{{cite journal | vauthors = Balaguer P, Delfosse V, Grimaldi M, Bourguet W | title = Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses | journal = Comptes Rendus Biologies | volume = 340 | issue = 9β10 | pages = 414β420 | date = 1 September 2017 | pmid = 29126514 | doi = 10.1016/j.crvi.2017.08.002 | series = Endocrine disruptors / Les perturbateurs endocriniens | doi-access = free }}</ref>
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