Editing Essential thrombocythemia (section)

==Diagnosis==
The following revised diagnostic criteria for essential thrombocythemia were proposed in 2005.<ref name="Campbell">{{cite journal |vauthors=Campbell PJ, Green AR |volume= 2005|pages=201–208 |year=2005 |pmid=16304381 |doi=10.1182/asheducation-2005.1.201 |url=https://ashpublications.org/hematology/article/2009/1/621/19882/Pathogenesis-and-management-of-essential |title= Management of polycythemia vera and essential thrombocythemia |journal= Hematology|url-access=subscription }}</ref> The diagnosis requires the presence of both A criteria together with B3 to B6, or of criterion A1 together with B1 to B6.<ref name="WHO" /> The criteria are as follows:<ref name="WHO">{{cite journal |last1=Vardiman |first1=JW |last2=Thiele |first2=J |last3=Arber |first3=DA |last4=Brunning |first4=RD |last5=Borowitz |first5=MJ |last6=Porwit |first6=A |last7=Harris |first7=NL |last8=Le Beau |first8=MM |last9=Hellström-Lindberg |first9=E |last10=Tefferi |first10=A |last11=Bloomfield |first11=CD |title=The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes |journal=Blood |date=July 2009 |volume=114 |issue=5 |pages=937–951 |doi=10.1182/blood-2009-03-209262 |pmid=19357394 |s2cid=3101472 |url=https://ashpublications.org/blood/article/114/5/937/103719/The-2008-revision-of-the-World-Health-Organization }}</ref>
* A1. [[Platelet count]] > 400 × 10<sup>3</sup>/μL for at least 2 months.
* A2. Acquired V617F [[JAK2]] mutation present
* B1. No cause for a reactive thrombocytosis
** normal inflammatory indices
* B2. No evidence of iron deficiency
** stainable iron in the bone marrow or normal red cell mean corpuscular volume
* B3. No evidence of [[polycythemia vera]]
** hematocrit < midpoint of normal range or normal red cell mass in presence of normal iron stores
* B4. No evidence of [[chronic myeloid leukemia]]
** But the [[Philadelphia chromosome]] may be present in up to 10% of cases. Patients with the Philadelphia chromosome have a potential for the development of acute leukemia, especially [[acute lymphocytic leukemia]].
* B5. No evidence of [[myelofibrosis]]
** no collagen fibrosis and ≤ grade 2 reticulin fibrosis (using 0–4 scale)
* B6. No evidence of a [[myelodysplastic syndrome]]
** no significant dysplasia
** no cytogenetic abnormalities suggestive of [[myelodysplasia]]