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GABAA receptor
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===Subunits=== GABA<sub>A</sub> receptors are members of the large pentameric ligand gated ion channel (previously referred to as "''Cys''-loop" receptors) super-family of evolutionarily related and structurally similar [[ligand-gated ion channel]]s that also includes [[nicotinic acetylcholine receptor]]s, [[glycine receptor]]s, and the [[5-HT3 receptor|5HT<sub>3</sub> receptor]]. There are numerous subunit [[isoform]]s for the GABA<sub>A</sub> receptor, which determine the receptor's agonist affinity, chance of opening, conductance, and other properties.<ref name="Cossart">{{cite journal | vauthors = Cossart R, Bernard C, Ben-Ari Y | title = Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies | journal = Trends in Neurosciences | volume = 28 | issue = 2 | pages = 108–115 | date = February 2005 | pmid = 15667934 | doi = 10.1016/j.tins.2004.11.011 | s2cid = 1424286 }}</ref> In humans, the units are as follows: * six types of α subunits ([[GABRA1]], [[GABRA2]], [[GABRA3]], [[GABRA4]], [[GABRA5]], [[GABRA6]]) * three βs ([[GABRB1]], [[GABRB2]], [[GABRB3]]) * three γs ([[GABRG1]], [[GABRG2]], [[GABRG3]]) * as well as a δ ([[GABRD]]), an ε ([[GABRE]]), a π ([[GABRP]]), and a θ ([[GABRQ]]) There are three ρ units ([[GABRR1]], [[GABRR2]], [[GABRR3]]); however, these do not coassemble with the classical GABA<sub>A</sub> units listed above,<ref name="Enz">{{cite journal | vauthors = Enz R, Cutting GR | title = Molecular composition of GABAC receptors | journal = Vision Research | volume = 38 | issue = 10 | pages = 1431–1441 | date = May 1998 | pmid = 9667009 | doi = 10.1016/S0042-6989(97)00277-0 | s2cid = 14457042 | doi-access = }}</ref> but rather homooligomerize to form [[GABAA-rho receptor|GABA<sub>A</sub>-ρ receptors]] (formerly classified as GABA<sub>C</sub> receptors but now this [[nomenclature]] has been deprecated<ref name="pmid18760291">{{cite journal | vauthors = Olsen RW, Sieghart W | title = GABA A receptors: subtypes provide diversity of function and pharmacology | journal = Neuropharmacology | volume = 56 | issue = 1 | pages = 141–148 | date = January 2009 | pmid = 18760291 | pmc = 3525320 | doi = 10.1016/j.neuropharm.2008.07.045 }}</ref>).
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