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Hashimoto's thyroiditis
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=== Symptoms === Many symptoms are attributed to the development of Hashimoto's thyroiditis. Symptoms can include: [[Fatigue (medicine)|fatigue]], weight gain, pale or puffy face, feeling cold, [[Arthralgia|joint]] and [[Myalgia|muscle pain]], [[constipation]], dry and thinning hair, [[Menorrhagia|heavy menstrual flow]] or [[Metrorrhagia|irregular periods]], [[Depression (mood)|depression]], a [[Bradycardia|slowed heart rate]], [[Infertility|problems getting pregnant]], [[miscarriages]],<ref>{{Cite news|url=https://www.mayoclinic.org/diseases-conditions/hashimotos-disease/symptoms-causes/syc-20351855|title=Hashimoto's disease – Symptoms and causes|work=Mayo Clinic|access-date=2018-10-05|language=en|archive-date=29 October 2018|archive-url=https://web.archive.org/web/20181029084838/https://www.mayoclinic.org/diseases-conditions/hashimotos-disease/symptoms-causes/syc-20351855|url-status=live}}</ref> and [[myopathy]].<ref name="Fariduddin-2024" /> Some patients in the early stage of the disease may experience symptoms of [[hyperthyroidism]] due to the release of thyroid hormones from intermittent thyroid destruction<ref name="Mincer2022" /><ref name="Dyrka-2024">{{cite journal | vauthors = Dyrka K, Obara-Moszyńska M, Niedziela M | title = Autoimmune thyroiditis: an update on treatment possibilities | journal = Endokrynologia Polska | volume = 75 | issue = 5 | pages = 461–472 | date = 2024 | pmid = 39475129 | doi = 10.5603/ep.100701 | doi-access = free }}</ref> (also called "destructive thyrotoxicosis").<ref name="Ramos-Levi2023" /> In non-medical settings, the term "flare" is used to refer to a sudden exacerbation of symptoms, whether hyper or hypo.<ref>{{Cite web |title=Hashimoto's Thyroiditis: Symptoms, Causes, and Treatments |url=https://www.webmd.com/women/hashimotos-thyroiditis-symptoms-causes-treatments |access-date=2025-01-08 |website=WebMD |language=en |vauthors=Dunkin MA}}</ref><!-- Hi Editors, the claim that "the term flare is used in non-medical settings" is a non-medical claim so it does not require a MEDRS source. <!-- If you want to make *medical* claims about sudden exacerbations of symptoms (e.g. that they might have specific causes) you need to back that up with a MEDRS-level source. --> While most symptoms are attributed to hypothyroidism, similar symptoms are observed in Hashimoto's patients with normal thyroid hormone levels.<ref name=":6">{{Cite book | vauthors = Jonklaas J |title=DeGroot's Endocrinology: Basic Science and Clinical Practice |year=2023 |isbn=978-0-323-69412-4 |edition=8th |pages=1234–1248 |chapter=Hypothyroidism|publisher=Elsevier Health Sciences }}</ref><ref name="Hegedüs-2022" /><ref name="Klubo-Gwiezdzinska-2022" /> According to one study, these symptoms may include lower quality of life, and issues of the "digestive system ([[abdominal distension]], constipation and diarrhea), endocrine system (chilliness, gain weight and facial [[edema]]), [[Neuropsychiatry|neuropsychiatric]] system (forgetfulness, anxiety, depressed, fatigue, insomnia, irritability, and indifferent [''sic'']) and [[Mucocutaneous disease|mucocutaneous]] system (dry skin, [[pruritus]], and hair loss)."<ref name="Li-2024">{{cite journal | vauthors = Li J, Huang Q, Sun S, Zhou K, Wang X, Pan K, Zhang Y, Wang Y, Han Q, Si C, Li S, Fan S, Li D | title = Thyroid antibodies in Hashimoto's thyroiditis patients are positively associated with inflammation and multiple symptoms | journal = Scientific Reports | volume = 14 | issue = 1 | pages = 27902 | date = November 2024 | pmid = 39537841 | pmc = 11561229 | doi = 10.1038/s41598-024-78938-7 | bibcode = 2024NatSR..1427902L }}</ref>
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