Editing Hereditary multiple exostoses (section)

=== Possible connection to autism ===
Some parents of children with HME have observed [[autism]]-like social problems in their children. To explore those observations more deeply, a 2012 study by the [[Sanford-Burnham Medical Research Institute]] used a mouse model of HME to observe cognitive function. The findings indicated that the mutant mice endorsed three autistic characteristics: social impairment, impairments in [[ultrasonic vocalization]], and repetitive behavior.<ref>{{cite journal | vauthors = Irie F, Badie-Mahdavi H, Yamaguchi Y | title = Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 13 | pages = 5052–5056 | date = March 2012 | pmid = 22411800 | pmc = 3323986 | doi = 10.1073/pnas.1117881109 | doi-access = free | bibcode = 2012PNAS..109.5052I }}</ref>