Editing Infliximab (section)

====Fistulizing disease====
Infliximab was first used for closure of fistulae in Crohn's disease in 1999. In a 94-patient, phase II clinical trial, the researchers showed infliximab was effective in closing fistulae between the [[skin]] and [[bowel]] in 56–68% of patients.<!--
--><ref name=Present>{{cite journal | vauthors = Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, Schaible TF, van Deventer SJ | title = Infliximab for the treatment of fistulas in patients with Crohn's disease | journal = [[The New England Journal of Medicine]] | volume = 340 | issue = 18 | pages = 1398–405 | date = May 1999 | pmid = 10228190 | doi = 10.1056/NEJM199905063401804 | url = https://pure.uva.nl/ws/files/3156092/7456_77284y.pdf | access-date = 5 July 2019 | archive-date = 18 February 2019 | archive-url = https://web.archive.org/web/20190218233244/https://pure.uva.nl/ws/files/3156092/7456_77284y.pdf | url-status = live }}</ref> <!--
-->A large, 296-patient Phase III clinical trial called the ACCENT 2 trial showed infliximab was additionally beneficial in maintaining closure of fistulae, with almost two-thirds of all patients treated with the three initial doses of infliximab having a fistula response after 14 weeks, and 36% of patients maintaining closure of fistulae after a year, compared with 19% who received [[placebo]] therapy. This final trial resulted in the FDA approval of the drug to treat fistulizing disease.<!--
--><ref name=ACCENT2>{{cite journal | vauthors = Sands BE, Anderson FH, Bernstein CN, Chey WY, Feagan BG, Fedorak RN, Kamm MA, Korzenik JR, Lashner BA, Onken JE, Rachmilewitz D, Rutgeerts P, Wild G, Wolf DC, Marsters PA, Travers SB, Blank MA, van Deventer SJ | title = Infliximab maintenance therapy for fistulizing Crohn's disease | journal = [[The New England Journal of Medicine]] | volume = 350 | issue = 9 | pages = 876–85 | date = February 2004 | pmid = 14985485 | doi = 10.1056/NEJMoa030815 | doi-access = free }}</ref>