Editing Inotrope (section)

==Negative inotropic agents==
Negative inotropic agents decrease myocardial [[contractility]] and are used to decrease cardiac workload in conditions such as [[Angina pectoris|angina]]. While negative inotropism may precipitate or exacerbate heart failure in the short term, certain beta blockers (e.g. [[carvedilol]], [[bisoprolol]] and [[metoprolol]]) have been believed to reduce long-term [[morbidity]] and [[death|mortality]] in [[congestive heart failure]].<ref>{{cite journal | vauthors = Xu T, Huang Y, Zhou H, Bai Y, Huang X, Hu Y, Xu D, Zhang Y, Zhang J | display-authors = 6 | title = β-blockers and risk of all-cause mortality in patients with chronic heart failure and atrial fibrillation-a meta-analysis | journal = BMC Cardiovascular Disorders | volume = 19 | issue = 1 | pages = 135 | date = June 2019 | pmid = 31159740 | pmc = 6547467 | doi = 10.1186/s12872-019-1079-2 | doi-access = free }}</ref>

Examples of negative inotropic agents include:

*[[Beta blocker]]s<ref>{{cite journal | vauthors = Chatterjee S, Biondi-Zoccai G, Abbate A, D'Ascenzo F, Castagno D, Van Tassell B, Mukherjee D, Lichstein E | display-authors = 6 | title = Benefits of β blockers in patients with heart failure and reduced ejection fraction: network meta-analysis | journal = BMJ | volume = 346 | issue = jan16 1 | pages = f55 | date = January 2013 | pmid = 23325883 | pmc = 3546627 | doi = 10.1136/bmj.f55 }}</ref>
*Non-dihydropyridine [[Calcium channel blocker]]s
**[[Diltiazem]]
**[[Verapamil]]

Class IA [[antiarrhythmics]] such as
*[[Quinidine]]
*[[Procainamide]]
*[[Disopyramide]]

Class IC antiarrhythmics such as
*[[Flecainide]]
*[[Isovoacangine]]
*[[Voacristine]]