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Janeway lesion
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==Pathophysiology== Pathologically, the lesion is described to be a [[abscess|microabscess]] of the [[dermis]] with marked [[necrosis]] and inflammatory infiltrate not involving the [[epidermis (skin)|epidermis]].<ref name = "Farrior">{{cite journal | last = Farrior | first = J.B. |author2=Silverman M.E. | title = A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis |journal = Chest | volume = 70 | issue = 2 | pages = 239β243 | year = 1976 | pmid = 947688 | doi = 10.1378/chest.70.2.239}}</ref> They are caused by septic emboli which deposit bacteria, forming microabscesses.<ref name="Mandell">Mandell, Douglas, ''Bennett's Principles and Practice of Infectious Diseases'', 7th ed., [[Churchill Livingstone]] (2009).</ref> Organisms may be cultured from the lesions.<ref name=Patterson2016>{{Cite book|chapter-url=https://books.google.com/books?id=Y-LTBQAAQBAJ&q=janeway|title=Weedon's Skin Pathology|last=Patterson|first=James W.|date=2016|publisher=Churchill Livingston|isbn=978-0-7020-5183-8|edition=4th|pages=239β240|language=en|chapter=8. The Vasculopathic Reaction Pattern}}</ref>
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