Editing Luteinizing hormone (section)

== Genes ==
The [[gene]] for the ''alpha subunit'' is located on [[chromosome 6]]q12.21.<ref name="Nagirnaja_2010">{{cite journal | vauthors = Nagirnaja L, Rull K, Uusküla L, Hallast P, Grigorova M, Laan M | title = Genomics and genetics of gonadotropin beta-subunit genes: Unique FSHB and duplicated LHB/CGB loci | journal = Molecular and Cellular Endocrinology | volume = 329 | issue = 1–2 | pages = 4–16 | date = November 2010 | pmid = 20488225 | pmc = 2954307 | doi = 10.1016/j.mce.2010.04.024 }}</ref>

The luteinizing hormone ''beta subunit'' gene is localized in the LHB/CGB gene cluster on [[chromosome 19]]q13.32.<ref name="Nagirnaja_2010" /> In contrast to the alpha gene activity, beta LH subunit gene activity is restricted to the pituitary gonadotropic cells. It is regulated by the [[gonadotropin-releasing hormone]] from the  [[hypothalamus]].<ref>{{cite journal | vauthors = Thackray VG, Mellon PL, Coss D | title = Hormones in synergy: regulation of the pituitary gonadotropin genes | journal = Molecular and Cellular Endocrinology | volume = 314 | issue = 2 | pages = 192–203 | date = January 2010 | pmid = 19747958 | doi = 10.1016/j.mce.2009.09.003 | pmc = 2815122 }}</ref> GnRH activates Egr1 which interacts with transcription factors NR5A1 and PITX1 at the gene promoter to up-regulate LHB transcription.<ref>{{cite journal | vauthors = Tremblay JJ, Drouin J | title = Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 2567–2576 | date = April 1999 | pmid = 10082522 | pmc = 84049 | doi = 10.1128/MCB.19.4.2567 }}</ref><ref>{{cite journal | vauthors = Dorn C, Ou Q, Svaren J, Crawford PA, Sadovsky Y | title = Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 13870–13876 | date = May 1999 | pmid = 10318795 | doi = 10.1074/jbc.274.20.13870 | doi-access = free }}</ref>