Editing Median lethal dose (section)

== Examples ==
Note: Comparing substances (especially drugs) to each other by LD<sub>50</sub> can be misleading in many cases due (in part) to differences in [[Effective dose (pharmacology)|effective dose]] (ED<sub>50</sub>). Therefore, it is more useful to compare such substances by [[therapeutic index]], which is simply the ratio of LD<sub>50</sub> to ED<sub>50</sub>.<ref>{{Cite web |date=2011-01-26 |title=Therapeutic index {{!}} CME at Pharmacology Corner |url=https://pharmacologycorner.com/therapeutic-index/ |access-date=2024-07-15 |website=pharmacologycorner.com |language=en-US}}</ref>

The following examples are listed in reference to LD<sub>50</sub> values, in descending order, and accompanied by LC<sub>50</sub> values, {bracketed}, when appropriate.

{| class="wikitable sortable"
|-wa
! Substance
! Animal, route
! class=unsortable| LD<sub>50</sub> <br /> {LC<sub>50</sub>} <br />
! data-sort-type="number"| LD<sub>50</sub> : g/kg <br /> {LC<sub>50</sub> : g/L} <br /> standardised
! class=unsortable| Reference
|-
| [[Water intoxication|Water]] ({{chem2|H2O}})
| rat, oral
| >{{ntsh|90000}}90,000&nbsp;mg/kg
| >90
| <ref>{{cite web|url=http://www.sciencelab.com/msds.php?msdsId=9927321 |title=Material Safety Data Sheet Water MSDS |at=Section 11: Toxicological Information for the LD<sub>50</sub> verification |access-date=2012-05-09 |archive-url=https://web.archive.org/web/20120902122244/http://www.sciencelab.com/msds.php?msdsId=9927321 |archive-date=2012-09-02 |url-status=dead }}</ref>
|-
| [[Sucrose]] (table sugar)
| rat, oral
| {{ntsh|29700}}29,700&nbsp;mg/kg
| 29.7
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/SU/sucrose.html|title=Safety (MSDS) data for sucrose|url-status=dead|archive-url=https://web.archive.org/web/20110612032043/http://msds.chem.ox.ac.uk/SU/sucrose.html|archive-date=2011-06-12|website=ox.ac.uk}}</ref>
|-
| [[Corn syrup]]
| rat, oral
| {{ntsh|25800}}25,800&nbsp;mg/kg
| 25.8
| <ref>{{cite web|url=https://www.fishersci.com/store/msds?partNumber=S25339&productDescription=fisher-science-educationtrade-corn-syrup&vendorId=VN00115888&keyword=true&countryCode=US&language=en|title=Safety (MSDS) data for Corn Syrup|website=fishersci.com|access-date=2022-09-21|archive-date=2022-09-21|archive-url=https://web.archive.org/web/20220921201129/https://www.fishersci.com/store/msds?partNumber=S25339&productDescription=fisher-science-educationtrade-corn-syrup&vendorId=VN00115888&keyword=true&countryCode=US&language=en|url-status=live}}</ref>
|-
| [[Glucose]] (blood sugar)
| rat, oral
| {{ntsh|25800}}25,800&nbsp;mg/kg
| 25.8
| <ref>{{cite web|url=http://www.chem.utoronto.ca/~pmeindl/labs/msds%20files/glucose.pdf|title=Safety (MSDS) data for glucose|website=utoronto.ca|access-date=2016-12-31|archive-url=https://web.archive.org/web/20170101003021/http://www.chem.utoronto.ca/~pmeindl/labs/msds%20files/glucose.pdf|archive-date=2017-01-01|url-status=dead}}</ref>
|-
| [[Monosodium glutamate]] (MSG)
| rat, oral
| {{ntsh|16600}}16,600&nbsp;mg/kg
| 16.6
| <ref name="Walker00">{{cite journal | vauthors = Walker R, Lupien JR | title = The safety evaluation of monosodium glutamate | journal = The Journal of Nutrition | volume = 130 | issue = 4S Suppl | pages = 1049S–1052S | date = April 2000 | pmid = 10736380 | doi = 10.1093/jn/130.4.1049S | doi-access = free }}</ref>
|-
| [[Stevioside]] (from [[stevia]])
| mice and rats, oral
| {{ntsh|15000}}15,000&nbsp;mg/kg
| 15
| <ref>{{cite journal | vauthors = Toskulkao C, Chaturat L, Temcharoen P, Glinsukon T | title = Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species | journal = Drug and Chemical Toxicology | volume = 20 | issue = 1–2 | pages = 31–44 | year = 1997 | pmid = 9183561 | doi = 10.3109/01480549709011077 }}</ref>
|-
| [[Gasoline]] (petrol)
| rat
| {{ntsh|14063}}14,063&nbsp;mg/kg
| 14.0
| <ref>{{cite web | url=https://www.atsdr.cdc.gov/toxprofiles/tp72.pdf | title=Toxicological profile for gasoline | date=June 1995 | publisher=U.S. Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry | pages=47 | access-date=2020-01-05 | archive-url=https://web.archive.org/web/20170515140517/https://www.atsdr.cdc.gov/toxprofiles/tp72.pdf | archive-date=2017-05-15 | url-status=dead }}</ref>
|-
| [[Vitamin C]] (ascorbic acid)
| rat, oral
| {{ntsh|11900}}11,900&nbsp;mg/kg
| 11.9
| <ref>{{cite web|url=http://physchem.ox.ac.uk/MSDS/AS/ascorbic_acid.html |archive-url=https://archive.today/20070209221915/http://physchem.ox.ac.uk/MSDS/AS/ascorbic_acid.html |url-status=dead |archive-date=2007-02-09 |title=Safety (MSDS) data for ascorbic acid |access-date=2007-02-21 |date=2005-10-09 |publisher=[[Oxford University]] }}</ref>
|-
| [[Glyphosate]] (isopropylamine salt)
| rat, oral
| {{ntsh|10537}}10,537&nbsp;mg/kg
| 10.537
| <ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/38078#section=Non-Human-Toxicity-Values|title=Glyphosate-isopropylammonium|website=PubChem|access-date=2019-01-17|archive-date=2021-03-02|archive-url=https://web.archive.org/web/20210302061538/https://pubchem.ncbi.nlm.nih.gov/compound/38078#section=Non-Human-Toxicity-Values|url-status=live}}</ref>
|-
| [[Lactose]] (milk sugar)
| rat, oral
| {{ntsh|10000}}10,000&nbsp;mg/kg
| 10
| <ref>{{cite web|url=http://www.sciencestuff.com/msds/C1958.pdf|title=Safety (MSDS) data for Lactose|access-date=2016-12-31|archive-url=https://web.archive.org/web/20160803150146/http://www.sciencestuff.com/msds/C1958.pdf|archive-date=2016-08-03|url-status=dead}}</ref>
|-
| [[Aspartame]]
| mice, oral
| {{ntsh|10000}}10,000&nbsp;mg/kg
| 10
| <ref>{{cite web|url=https://www.spectrumchemical.com/MSDS/A6051.pdf|archive-url=https://web.archive.org/web/20161226221445/https://www.spectrumchemical.com/MSDS/A6051.pdf|url-status=dead|archive-date=2016-12-26|title=Material Safety Data Sheet: Aspartame|publisher=Spectrum}}</ref>
|-
| [[Urea]] ({{chem2|OC(NH2)2}})
| rat, oral
| {{ntsh|8471}}8,471&nbsp;mg/kg
| 8.471
| <ref>{{cite web |url=http://www.sciencelab.com/msds.php?msdsId=9927317 |title=Safety (MSDS) data for urea |access-date=2015-03-06 |date=2015-03-06 |at=Section 11: Toxicological Information for the LD<sub>50</sub> verification |archive-url=https://web.archive.org/web/20150301225811/http://www.sciencelab.com/msds.php?msdsId=9927317 |archive-date=2015-03-01 |url-status=dead }}</ref>
|-
| [[Cyanuric acid]]
| rat, oral
| {{ntsh|7700}}7,700&nbsp;mg/kg
| 7.7
| <ref name="Babayan">A.A. Babayan, A.V.Aleksandryan, "Toxicological characteristics of melamine cyanurate, melamine and cyanuric acid", Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny, Vol.25, 345–9 (1985). Original article in Russian.</ref>
|-
| [[Cadmium sulfide]] (CdS)
| rat, oral
| {{ntsh|7080}}7,080&nbsp;mg/kg
| 7.08
| <ref>[http://www.alfa.com/content/msds/german/A14544.pdf Advanced Search – Alfa Aesar – A Johnson Matthey Company] {{Webarchive|url=https://web.archive.org/web/20150724053453/http://www.alfa.com/content/msds/german/A14544.pdf |date=2015-07-24 }}. Alfa.com. Retrieved on 2013-07-17.</ref>
|-
| [[Ethanol]] ({{chem2|CH3CH2OH}})
| rat, oral
| {{ntsh|7060}}7,060&nbsp;mg/kg
| 7.06
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/ET/ethyl_alcohol.html|title=Safety (MSDS) data for ethyl alcohol|url-status=dead|archive-url=https://web.archive.org/web/20110714040451/http://msds.chem.ox.ac.uk/ET/ethyl_alcohol.html|archive-date=2011-07-14|website=ox.ac.uk}}</ref>
|-
| Sodium [[Sarin#Production and structure|isopropyl methylphosphonic acid]] (IMPA, metabolite of [[sarin]])
| rat, oral
| {{ntsh|6860}}6,860&nbsp;mg/kg
| 6.86
| <ref>{{Cite report|title=Mammalian Toxological Evaluation of DIMP and DCBP (Phase 3 – IMPA)|type=Final report| vauthors = Mecler FJ |date=May 1981|publisher=Litton Bionetics, Inc.|quote=The oral LD50 values for the test material, IMPA, were 7650 and 6070 mg/kg for male and female rats, respectively.|url=http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA107574|archive-url=https://web.archive.org/web/20131004070929/http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA107574|url-status=dead|archive-date=October 4, 2013}}</ref>
|-
| [[Melamine]]
| rat, oral
| {{ntsh|6000}}6,000&nbsp;mg/kg
| 6
| <ref name="Babayan" />
|-
| [[Taurine]]
| rat, oral
| {{ntsh|5000}}5,000&nbsp;mg/kg
| 5
| <ref>{{cite web|url=http://datasheets.scbt.com/sc-202354.pdf|title=Safety data for taurine|website=scbt.com|access-date=2017-01-18|archive-url=https://web.archive.org/web/20170118214915/http://datasheets.scbt.com/sc-202354.pdf|archive-date=2017-01-18|url-status=dead}}</ref>
|-
| [[Melamine cyanurate]]
| rat, oral
| {{ntsh|4100}}4,100&nbsp;mg/kg
| 4.1
| <ref name="Babayan" />
|-
| [[Fructose]] (fruit sugar)
| rat, oral
| 4,000&nbsp;mg/kg
| 4
| <ref>{{cite web|url=https://www.sciencelab.com/msds.php?msdsId=9927537|title=Safety (MSDS) data for fructose|website=sciencelab.com|access-date=2016-12-31|archive-url=https://web.archive.org/web/20170702044942/http://www.sciencelab.com/msds.php?msdsId=9927537|archive-date=2017-07-02|url-status=dead}}</ref>
|-
| [[Sodium molybdate]] ({{chem2|Na2MoO4}})
| rat, oral
| 4,000&nbsp;mg/kg
| 4
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/SO/sodium_molybdate.html|title=Safety (MSDS) data for sodium molybdate|url-status=dead|archive-url=https://web.archive.org/web/20110128034147/http://msds.chem.ox.ac.uk/SO/sodium_molybdate.html|archive-date=2011-01-28|website=ox.ac.uk}}</ref>
|-
| [[Salt poisoning|Sodium chloride]] (table salt)
| rat, oral
| 3,000&nbsp;mg/kg
| 3
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/MSDS/SO/sodium_chloride.html|title=Safety (MSDS) data for sodium chloride|url-status=dead|archive-url=https://web.archive.org/web/20110607224738/http://msds.chem.ox.ac.uk/SO/sodium_chloride.html|archive-date=2011-06-07|website=ox.ac.uk}}</ref>
|-
| [[Paracetamol poisoning|Paracetamol]] (acetaminophen)
| rat, oral
| 2000&nbsp;mg/kg
| 2
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/AC/acetylsalicylic_acid.html|title=Safety (MSDS) data for acetylsalicylic acid|url-status=dead|archive-url=https://web.archive.org/web/20110716144023/http://msds.chem.ox.ac.uk/AC/acetylsalicylic_acid.html|archive-date=2011-07-16|website=ox.ac.uk}}</ref>
|-
| [[Aspirin]] (acetylsalicylic acid)
| rat, oral
| 1,600&nbsp;mg/kg
| 1.6
| <ref>{{cite web|website=Millipore Sigma|publisher=Merck KGaA|url=https://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=US&language=en&productNumber=P0300000&brand=SIAL&PageToGoToURL=https%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fsearch%3Fterm%3DParacetamol%26interface%3DProduct%2520Name%26N%3D0%2B%26mode%3Dmode%2520matchpartialmax%26lang%3Den%26region%3DUS%26focus%3DproductN%3D0%2520220003048%2520219853286%2520219853121|title=Safety (MSDS) data for paracetamol|access-date=2020-01-06|archive-date=2021-03-02|archive-url=https://web.archive.org/web/20210302004449/https://www.sigmaaldrich.com/MSDS/MSDS/DisplayMSDSPage.do?country=US&language=en&productNumber=P0300000&brand=SIAL&PageToGoToURL=https%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fsearch%3Fterm%3DParacetamol%26interface%3DProduct%2520Name%26N%3D0%2B%26mode%3Dmode%2520matchpartialmax%26lang%3Den%26region%3DUS%26focus%3DproductN%3D0%2520220003048%2520219853286%2520219853121|url-status=live}}</ref>
|-
| [[Delta-9-tetrahydrocannabinol]] (THC)
| rat, oral
| 1,270&nbsp;mg/kg
| 1.27
| <ref>{{cite journal | vauthors = Rosenkrantz H, Heyman IA, Braude MC | title = Inhalation, parenteral and oral LD50 values of delta 9-tetrahydrocannabinol in Fischer rats | journal = Toxicology and Applied Pharmacology | volume = 28 | issue = 1 | pages = 18–27 | date = April 1974 | pmid = 4852457 | doi = 10.1016/0041-008X(74)90126-4 }}</ref>
|-
| [[Cannabidiol]] (CBD)
| rat, oral
| 980&nbsp;mg/kg
| 0.98
| <ref>{{cite web|url=http://www.chemblink.com/MSDS/MSDSFiles/13956-29-1_Clear%20Synth.pdf|title=MSDS of CBD|website=chemblink.com|access-date=2016-12-26|archive-url=https://web.archive.org/web/20161226150441/http://www.chemblink.com/MSDS/MSDSFiles/13956-29-1_Clear%20Synth.pdf|archive-date=2016-12-26|url-status=dead}}</ref>
|-
| [[Methanol toxicity|Methanol]] ({{chem2|CH3OH}})
| human, oral
| {{ntsh|5628}}810&nbsp;mg/kg
| 0.81
| <ref>{{cite web|url=http://www.antizol.com/mpoisono.htm|archive-url=https://web.archive.org/web/20111005043548/http://www.antizol.com/mpoisono.htm|url-status=dead|archive-date=2011-10-05|title=Methanol Poisoning Overview|website=antizol.com}}</ref>
|-
|[[TNT|Trinitrotoluene]] (TNT)
|rat, oral
|790&nbsp;mg/kg
|0.790
|
|-
| [[Arsenic poisoning|Arsenic]] (As)
| rat, oral
| 763&nbsp;mg/kg
| 0.763
| <ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/5359596#section=Non-Human-Toxicity-Values|title=Arsenic|website=PubChem|access-date=2020-01-06|archive-date=2021-05-12|archive-url=https://web.archive.org/web/20210512235921/https://pubchem.ncbi.nlm.nih.gov/compound/5359596#section=Non-Human-Toxicity-Values|url-status=live}}</ref>
|-
| [[Ibuprofen]]
| rat, oral
| 636&nbsp;mg/kg
| 0.636
| <ref>{{cite web|url=https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3099|title=Ibuprofen – National Library of Medicine HSDB Database|website=toxnet.nlm.nih.gov|access-date=2016-12-26|archive-date=2018-08-04|archive-url=https://web.archive.org/web/20180804014036/https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+3099|url-status=live}}</ref>
|-
| [[Formaldehyde]] ({{chem2|CH2O}})
| rat, oral
| 600–800&nbsp;mg/kg
| 0.6
| <ref>{{cite web|url=http://www.inchem.org/documents/sids/sids/FORMALDEHYDE.pdf|title=Formaldehyde SIDS Initial Assessment Report|website=inchem.org|access-date=2016-12-26|archive-url=https://web.archive.org/web/20180613195125/http://www.inchem.org/documents/sids/sids/formaldehyde.pdf|archive-date=2018-06-13|url-status=dead}}</ref>
|-
| [[Solanine]] (main alkaloid in the several plants in ''[[Solanaceae]]'' amongst them ''[[Solanum tuberosum]]'')
| rat, oral (2.8&nbsp;mg/kg human, oral)
| {{ntsh|590}}590&nbsp;mg/kg
| 0.590
|  <ref>{{cite web|url=https://chem.nlm.nih.gov/chemidplus/rn/20562-02-1|title=Solanine – National Library of Medicine HSDB Database|website=toxnet.nlm.nih.gov|access-date=2019-01-17|archive-date=2021-01-19|archive-url=https://web.archive.org/web/20210119060749/https://chem.nlm.nih.gov/chemidplus/rn/20562-02-1|url-status=live}}</ref>
|-
| [[ADBAC|Alkyl dimethyl benzalkonium chloride]] (ADBAC)
| rat, oral <br /> fish, immersion <br /> aquatic invertebrates, immersion
| 304.5&nbsp;mg/kg <br /> {0.28&nbsp;mg/L} <br /> {0.059&nbsp;mg/L}
| 0.3045 <br /> {0.00028} <br /> {0.000059}
|<ref name=epaRED>{{cite report
 |title=Reregistration Eligibility Decision for Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC) 
 |publisher=[[United States Environmental Protection Agency|U.S. Environmental Protection Agency]] Office of Prevention, Pesticides, and Toxic Substances 
 |editor=Frank T. Sanders 
 |date=August 2006 
 |url=http://www.epa.gov/oppsrrd1/REDs/adbac_red.pdf 
 |pages=114 
 |access-date=2009-03-31 
 |url-status=dead 
 |archive-url=https://web.archive.org/web/20091024165642/http://www.epa.gov/oppsrrd1/REDs/adbac_red.pdf 
 |archive-date=2009-10-24 
}}</ref>
|-
| [[Coumarin]] ([[benzopyrone]], from ''[[Cinnamomum aromaticum]]'' and other plants)
| rat, oral
| 293&nbsp;mg/kg
| 0.293
| <ref>[http://www.palomar.edu/ehs/Chemistry%20MSDS/COUMARIN.pdf Coumarin Material Safety Data Sheet (MSDS)] {{webarchive|url=https://web.archive.org/web/20041021205840/http://www.palomar.edu/ehs/Chemistry%20MSDS/COUMARIN.pdf |date=2004-10-21 }}</ref>
|-
| [[Psilocybin]] (from [[Psilocybin mushroom|psilocybin mushrooms]])
| mouse, oral
| 280&nbsp;mg/kg
| 0.280
| <ref>{{Cite book|url=https://books.google.com/books?id=WPWsZNvOqVAC&pg=PA211|title=Handbook of Mushroom Poisoning: Diagnosis and Treatment| vauthors = Rumack BH, Spoerke DJ |date=27 September 1994|publisher=CRC Press|via=Google Books|isbn=978-0-8493-0194-0}}</ref>
|-
| [[Hydrochloric acid]] (HCl)
| rat, oral
| 238–277&nbsp;mg/kg
| 0.238
| <ref>{{cite web |url=https://fscimage.fishersci.com/msds/11155.htm |title=Material Safety Data Sheet: Hydrochloric acid 32-38% solution |date=1 April 2008 |publisher=Fisher |access-date=24 December 2020 |archive-date=6 May 2021 |archive-url=https://web.archive.org/web/20210506124743/http://fscimage.fishersci.com/msds/11155.htm |url-status=live }}</ref>
|-
| [[Ketamine]]
| rat, intraperitoneal
| 229&nbsp;mg/kg
| 0.229
| <ref>{{cite web|url=https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ketamine_508.pdf|title=Ketamine|website=nih.gov|access-date=2016-12-26|archive-date=2021-03-20|archive-url=https://web.archive.org/web/20210320091848/https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ketamine_508.pdf|url-status=live}}</ref>
|-
| [[Caffeine]]
| rat, oral
| 192&nbsp;mg/kg
| 0.192
| <ref>{{cite journal | vauthors = Boyd EM | title = The acute oral toxicity of caffeine | journal = Toxicology and Applied Pharmacology | volume = 1 | issue = 3 | pages = 250–257 | date = May 1959 | pmid = 13659532 | doi = 10.1016/0041-008X(59)90109-7 | bibcode = 1959ToxAP...1..250B }}</ref>
|-
| [[Arsenic trisulfide]] ({{chem2|As2S3}})
| rat, oral
| 185–6,400&nbsp;mg/kg
| 0.185–6.4
| <ref>{{cite web|url=http://www.valero.com/V_MSDS/SpentMetalCatalyst901.pdf|archive-url=https://web.archive.org/web/20110928045935/http://www.valero.com/V_MSDS/SpentMetalCatalyst901.pdf|archive-date=2011-09-28|title=Material Safety Data Sheet – Spent Metal Catalyst}}</ref>
|-
| [[Sodium nitrite]] ({{chem2|NaNO2}})
| rat, oral
| 180&nbsp;mg/kg
| 0.18
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/MSDS/SO/sodium_nitrite.html|title=Safety (MSDS) data for sodium nitrite|website=ox.ac.uk}}{{dead link|date=January 2020}}</ref>
|-
| [[MDMA|Methylenedioxymethamphetamine]] (MDMA)
| rat, oral
| 160&nbsp;mg/kg
| 0.18
| <ref>{{cite journal | vauthors = Gable RS | title = Acute toxic effects of club drugs | journal = Journal of Psychoactive Drugs | volume = 36 | issue = 3 | pages = 303–313 | date = September 2004 | pmid = 15559678 | doi = 10.1080/02791072.2004.10400031 | s2cid = 30689421 }}</ref>
|-
| [[Uranyl acetate dihydrate]] ({{chem2|UO2(CH3COO)2}})
| mouse, oral
| 136&nbsp;mg/kg
| 0.136
| <ref name=Depluranium4>{{cite web|url=https://www.who.int/ionizing_radiation/pub_meet/en/Depluranium4.pdf|title=Chemical toxicity of uranium|website=who.int|access-date=2020-10-05|archive-date=2021-03-09|archive-url=https://web.archive.org/web/20210309174346/https://www.who.int/ionizing_radiation/pub_meet/en/Depluranium4.pdf|url-status=live}}</ref>
|-
| [[Dichlorodiphenyltrichloroethane]] (DDT)
| mouse, oral
| 135&nbsp;mg/kg
| 0.135
| <ref>{{cite book |doi=10.1007/978-3-0348-6809-9_3 |chapter=Dose-Mortality Relationships in Animals |title=DDT: The Insecticide Dichlorodiphenyltrichloroethane and Its Significance / Das Insektizid Dichlordiphenyltrichloräthan und Seine Bedeutung |year=1959 | vauthors = Hayes WJ, Simmons SW, Knipling EF |pages=18–40 |isbn=978-3-0348-6796-2 }}</ref>
|-
| [[Uranium]] (U)
| mice, oral 
| {{ntsh|114}}114&nbsp;mg/kg (estimated)
| 0.114
| <ref name=Depluranium4/>
|-
| [[Bisoprolol]]
| mouse, oral
| 100&nbsp;mg/kg
| 0.1
| <ref>{{cite web|url=http://www.drugbank.ca/drugs/DB00612|title=Bisoprolol|website=www.drugbank.ca|access-date=2012-06-13|archive-date=2020-06-17|archive-url=https://web.archive.org/web/20200617011336/https://www.drugbank.ca/drugs/DB00612|url-status=live}}</ref>
|-
| [[Cocaine]]
| mouse, oral
| 96&nbsp;mg/kg
| 0.096
| <ref>{{cite web|url=https://www.drugbank.ca/drugs/DB00907|title=Cocaine|website=www.drugbank.ca|access-date=2016-12-26|archive-url=https://web.archive.org/web/20161120184636/http://www.drugbank.ca/drugs/DB00907|archive-date=2016-11-20|url-status=dead}}</ref>
|-
| [[Cobalt(II) chloride]] ({{chem2|CoCl2}})
| rat, oral
| 80&nbsp;mg/kg
| 0.08
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/CO/cobalt_II_chloride.html|title=Safety (MSDS) data for cobalt (II) chloride|url-status=dead|archive-url=https://web.archive.org/web/20110407222057/http://msds.chem.ox.ac.uk/CO/cobalt_II_chloride.html|archive-date=2011-04-07|website=ox.ac.uk}}</ref>
|-
| [[Cadmium oxide]] (CdO)
| rat, oral
| 72&nbsp;mg/kg
| 0.072
| <ref>[http://assets.chemportals.merck.de/documents/sds/emd/deu/de/1020/102015.pdf Safety (MSDS) data for cadmium oxide]{{Dead link|date=December 2021 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>
|-
| [[Thiopental sodium]] (used in [[lethal injection]])
| rat, oral
| 64&nbsp;mg/kg
| 0.064
| <ref>{{cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/thiopental_sodium#section=Non-Human-Toxicity-Values|title=Thiopental sodium|website=Pubchem|access-date=2017-01-06|archive-date=2021-01-26|archive-url=https://web.archive.org/web/20210126200735/https://pubchem.ncbi.nlm.nih.gov/compound/thiopental_sodium#section=Non-Human-Toxicity-Values|url-status=live}}</ref>
|-
| [[Demeton-S-methyl]]
| rat, oral
| 60&nbsp;mg/kg
| 0.060
| <ref>{{cite web|url=http://pmep.cce.cornell.edu/profiles/extoxnet/carbaryl-dicrotophos/demeton-s-methyl-ext.html|title=Demeton-s-methyl|date=September 1995|website=Extoxnet|access-date=2019-07-21|archive-date=2019-06-04|archive-url=https://web.archive.org/web/20190604152733/http://pmep.cce.cornell.edu/profiles/extoxnet/carbaryl-dicrotophos/demeton-s-methyl-ext.html|url-status=live}}</ref>
|-
| [[Methamphetamine]]
| rat, intraperitoneal
| 57&nbsp;mg/kg
| 0.057
| <ref>{{cite book |doi=10.1016/S0074-7742(09)88004-5 |chapter=Acute Methamphetamine Intoxication |title=New Concepts of Psychostimulant Induced Neurotoxicity |series=International Review of Neurobiology |year=2009 | vauthors = Kiyatkin EA, Sharma HS |volume=88 |pages=65–100 |pmid=19897075 |pmc=3145326 |isbn=978-0-12-374504-0 }}</ref>
|-
| [[Sodium fluoride]] (NaF)
| rat, oral
| 52&nbsp;mg/kg
| 0.052
| <ref>{{cite web|url=http://hazard.com/msds/mf/baker/baker/files/s3722.htm|title=Sodium fluoride|website=hazard.com|access-date=2011-07-31|archive-url=https://web.archive.org/web/20110928025825/http://hazard.com/msds/mf/baker/baker/files/s3722.htm|archive-date=2011-09-28|url-status=usurped}}</ref>
|-
| [[Nicotine]]
| mouse and rat, oral
human, smoking
| 50&nbsp;mg/kg
| 0.05
| <ref name=Mayer>{{cite journal | vauthors = Mayer B | title = How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century | journal = Archives of Toxicology | volume = 88 | issue = 1 | pages = 5–7 | date = January 2014 | pmid = 24091634 | pmc = 3880486 | doi = 10.1007/s00204-013-1127-0 | bibcode = 2014ArTox..88....5M }}</ref>
|-
| [[Pentaborane]]
| human, oral
| 50&nbsp;mg/kg
| 0.05
| <ref>{{cite web|url=http://cameochemicals.noaa.gov/chris/PTB.pdf|title=Pentaborane chemical and safety data|website=noaa.gov|access-date=2011-09-30|archive-date=2013-05-23|archive-url=https://web.archive.org/web/20130523073131/http://cameochemicals.noaa.gov/chris/PTB.pdf|url-status=live}}</ref>
|-
| [[Capsaicin]]
| mouse, oral
| 47.2&nbsp;mg/kg
| 0.0472
| <ref>{{cite web |url=http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296 |title=Capsaicin Material Safety Data Sheet |access-date=2007-07-13 |publisher=sciencelab.com |year=2007 |format=PDF |archive-url=https://web.archive.org/web/20070929083820/http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296 |archive-date=2007-09-29 |url-status=dead }}</ref>
|-
| [[Vitamin D3]] (cholecalciferol)
| rat, oral
| 37&nbsp;mg/kg
| 0.037
| <ref>{{cite web|url=http://www.hmdb.ca/system/metabolites/msds/000/000/792/original/HMDB00876.pdf?1358463052|title=MSDS for cholecalciferol crystalline|website=hmdb.ca|access-date=2016-12-26|archive-url=https://web.archive.org/web/20161226145455/http://www.hmdb.ca/system/metabolites/msds/000/000/792/original/HMDB00876.pdf?1358463052|archive-date=2016-12-26|url-status=dead}}</ref>
|-
| [[Piperidine]] (from [[black pepper]])
| rat, oral
| 30&nbsp;mg/kg
| 0.030
| <ref>{{cite web |url=https://fscimage.fishersci.com/msds/18940.htm |title=Material Safety Data Sheet: Piperidine |date=29 October 2007 |publisher=Fisher |access-date=24 December 2020 |archive-date=4 March 2016 |archive-url=https://web.archive.org/web/20160304203049/https://fscimage.fishersci.com/msds/18940.htm |url-status=live }}</ref>
|-
| [[Heroin]] (diamorphine)
| mouse, intravenous
| 21.8&nbsp;mg/kg
| 0.0218
| <ref>{{cite web|url=http://www.inchem.org/documents/pims/pharm/pim261f.htm|title=Diamorphine (PIM 261F, French)|website=www.inchem.org|access-date=2016-12-26|archive-url=https://web.archive.org/web/20160502211029/http://www.inchem.org/documents/pims/pharm/pim261f.htm|archive-date=2016-05-02|url-status=dead}}</ref>
|-
| [[Lysergic acid diethylamide]] (LSD)
| rat, intravenous
| 16.5&nbsp;mg/kg
| 0.0165
| <ref>[http://www.erowid.org/chemicals/lsd/lsd_death.shtml Erowid LSD (Acid) Vault : Fatalities / Deaths] {{Webarchive|url=https://web.archive.org/web/20210630093733/https://www.erowid.org/chemicals/lsd/lsd_death.shtml |date=2021-06-30 }}. Erowid.org. Retrieved on 2013-07-17.</ref>
|-
| [[Arsenic trioxide]] ({{chem2|As2O3}})
| rat, oral
| 14&nbsp;mg/kg
| 0.014
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/AR/arsenic_III_oxide.html|title=Safety (MSDS) data for arsenic trioxide|url-status=dead|archive-url=https://web.archive.org/web/20100309164500/http://msds.chem.ox.ac.uk/AR/arsenic_III_oxide.html|archive-date=2010-03-09|website=ox.ac.uk}}</ref>
|-
| Metallic [[arsenic]] (As)
| rat, [[intraperitoneal]]
| 13&nbsp;mg/kg
| 0.013
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/AR/arsenic.html|title=Safety (MSDS) data for metallic arsenic|url-status=dead|archive-url=https://web.archive.org/web/20110114204809/http://msds.chem.ox.ac.uk/AR/arsenic.html|archive-date=2011-01-14|website=ox.ac.uk}}</ref>
|-
| [[Sodium cyanide]] (NaCN)
| rat, oral
| 6.4&nbsp;mg/kg
| 0.0064
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/SO/sodium_cyanide.html|title=Safety (MSDS) data for sodium cyanide|url-status=dead|archive-url=https://web.archive.org/web/20090113101513/http://msds.chem.ox.ac.uk/SO/sodium_cyanide.html|archive-date=2009-01-13|website=ox.ac.uk}}</ref>
|-
| [[Chlorotoxin]] (CTX, from [[scorpion]]s)
| mice
| 4.3&nbsp;mg/kg
| 0.0043
| <ref>{{cite web|url=https://www.researchgate.net/file.PostFileLoader.html?id=55280ed4cf57d70b0a8b45af&assetKey=AS%3A273754658148357%401442279604492|title=Chlorotoxin: A Helpful Natural Scorpion Peptide to Diagnose Glioma and Fight Tumor Invasion|access-date=2016-12-27|archive-date=2016-12-28|archive-url=https://web.archive.org/web/20161228195033/https://www.researchgate.net/file.PostFileLoader.html?id=55280ed4cf57d70b0a8b45af&assetKey=AS%3A273754658148357%401442279604492|url-status=live}}</ref>
|-
| [[Hydrogen cyanide]] (HCN)
| mouse, oral
| 3.7&nbsp;mg/kg
| 0.0037
| <ref>{{cite web|url=http://msds.orica.com/pdf/shess-en-cds-010-000032505901.pdf|title=Safety (MSDS) data for hydrogen cyanide|website=orica.com|access-date=2016-12-26|archive-url=https://web.archive.org/web/20161226150416/http://msds.orica.com/pdf/shess-en-cds-010-000032505901.pdf|archive-date=2016-12-26|url-status=dead}}</ref>
|-
| [[Carfentanil]]
| rat, intravenous
| 3.39&nbsp;mg/kg
| 0.00339
| <ref>{{cite web|url=https://www.who.int/medicines/access/controlled-substances/Critical_Review_Carfentanil.pdf|title=Critical Review Carfentanil|access-date=2019-01-31|archive-date=2020-11-12|archive-url=https://web.archive.org/web/20201112031048/https://www.who.int/medicines/access/controlled-substances/Critical_Review_Carfentanil.pdf|url-status=live}}</ref>
|-
| [[Nicotine]] (from various ''[[Solanaceae]] genera'')
| mice, oral
| 3.3&nbsp;mg/kg
| 0.0033
| <ref name=Mayer/>
|-
| [[White phosphorus]] (P)
| rat, oral
| 3.03&nbsp;mg/kg
| 0.00303
| <ref>{{cite web|url=http://www.atsdr.cdc.gov/toxprofiles/tp103-c2.pdf|title=Hexachloroethane|access-date=2014-01-03|archive-date=2006-06-30|archive-url=https://web.archive.org/web/20060630161253/http://www.atsdr.cdc.gov/toxprofiles/tp103-c2.pdf|url-status=live}}</ref>
|-
| [[Strychnine]] (from ''[[Strychnos nux-vomica]]'')
| human, oral
| 1–2&nbsp;mg/kg (estimated)
| 0.001–0.002
| <ref>[http://www.inchem.org/documents/pims/chemical/pim507.htm INCHEM: Chemical Safety Information from Intergovernmental Organizations: Strychnine] {{Webarchive|url=https://web.archive.org/web/20150103231725/http://www.inchem.org/documents/pims/chemical/pim507.htm |date=2015-01-03 }}.</ref>
|-
| [[Aconitine]] (from ''[[Aconitum napellus]]'' and related species)
| human, oral
| {{ntsh|.080}}1–2&nbsp;mg/kg
| 0.001–0.002
|  <ref>{{cite journal | vauthors = Gao X, Hu J, Zhang X, Zuo Y, Wang Y, Zhu S | title = Research progress of aconitine toxicity and forensic analysis of aconitine poisoning | journal = Forensic Sciences Research | volume = 5 | issue = 1 | pages = 25–31 | date = 2018-04-09 | pmid = 32490307 | pmc = 7241456 | doi = 10.1080/20961790.2018.1452346 }}</ref>
|-
| [[Mercury(II) chloride]] ({{chem2|HgCl2}})
| rat, oral
| 1&nbsp;mg/kg
| 0.001
| <ref>{{cite web|url=http://www.labchem.com/tools/msds/msds/LC16590.pdf|title=Mercuric Chloride Safety Data Sheet|page=6|website=LabChem|access-date=2020-01-06|archive-url=https://web.archive.org/web/20191126231854/http://www.labchem.com/tools/msds/msds/LC16590.pdf|archive-date=2019-11-26|url-status=dead}}</ref>
|-
| [[Cantharidin]] (from [[blister beetle]]s)
| human, oral
| 500&nbsp;μg/kg
| 0.0005
| <ref>{{Cite book| vauthors = Meister RT, Sine C |title=Crop Protection Handbook | volume = 99 |publisher=Meister Pub Co |year=2013 |isbn=978-1892829269 |location=Willoughby, Ohio |pages=664 }}</ref>
|-
| [[Aflatoxin|Aflatoxin B1]] (from ''[[Aspergillus flavus]]'' mold)
| rat, oral
| 480&nbsp;μg/kg
| 0.00048
| <ref>{{cite web|url=http://msds.chem.ox.ac.uk/AF/aflatoxin_B1|title=Safety (MSDS) data for aflatoxin B1|url-status=dead|archive-url=https://web.archive.org/web/20100811121705/http://msds.chem.ox.ac.uk/AF/aflatoxin_B1.html|archive-date=2010-08-11|website=ox.ac.uk}}</ref>
|-
| [[Plutonium]] (Pu)
| dog, intravenous
| 320&nbsp;μg/kg
| 0.00032
| <ref>{{cite journal|url=https://fas.org/sgp/othergov/doe/lanl/pubs/00818013.pdf|journal=[[Los Alamos Science]]|title=Plutonium and Health &mdash; How great is the risk?|vauthors=Voelz GL, Buican IG|issue=26|pages=74–89|date=2000|access-date=2016-12-26|archive-date=2021-01-18|archive-url=https://web.archive.org/web/20210118020351/https://fas.org/sgp/othergov/doe/lanl/pubs/00818013.pdf|url-status=live}}</ref>
|-
| [[Bufotoxin]] (from ''[[Bufo]]'' toads)
| cat, intravenous
| {{ntsh|.300}}300&nbsp;μg/kg
| 0.0003
| <ref>{{cite web|url=https://chem.nlm.nih.gov/chemidplus/rn/464-81-3|title=Bufotoxin|work=ChemIDplus|publisher=U.S. National Library of Medicine|access-date=2016-12-27|archive-date=2021-01-19|archive-url=https://web.archive.org/web/20210119064413/https://chem.nlm.nih.gov/chemidplus/rn/464-81-3|url-status=live}}</ref>
|-
| [[Brodifacoum]]
| rat, oral
| 270&nbsp;μg/kg
| 0.00027
| <ref>{{cite web|url=http://www.inchem.org/documents/pims/chemical/pim077.htm |title=Brodifacoum (PDS) |publisher=Inchem.org |access-date=2017-12-05 |url-status=live |archive-url=https://web.archive.org/web/20131213084637/http://www.inchem.org/documents/pds/pds/pest57_e.htm |archive-date=2013-12-13 }}</ref>
|-
| [[Caesium-137]] ({{chem|137|Cs}})
| mouse, parenteral
| {{ntsh|.215}}21.5&nbsp;μCi/g 
| 0.000245
| <ref>{{cite book | vauthors = Moskalev YI |chapter=Biological Effects of Cesium-137| veditors = Lebedinskiĭ AV, Moskalev YI |title=Distribution, Biological Effects, and Migration of Radioactive Isotopes|series=Translation Series|publisher=United States Atomic Energy Commission|id=AEC-tr-7512|page=220|publication-date=April 1974|date=1961|chapter-url=https://books.google.com/books?id=K4wPAQAAMAAJ&pg=PA220|url=https://books.google.com/books?id=K4wPAQAAMAAJ}} [(21.5&nbsp;μCi/g) × (1000&nbsp;g/kg) × (0.0114&nbsp;μg/μCi) = 245&nbsp;μg/kg]</ref>
|-
|[[Sodium fluoroacetate]] ({{chem2|CH2FCOONa}})
|rat, oral
|220&nbsp;μg/kg
|0.00022
|<ref>{{Cite book| vauthors = Meister R, Since C |title=Crop Protection Handbook 2013 |publisher=Meister Pub Co|year=2013|isbn=9781892829269|location=Willoughby, Ohio|pages=664}}</ref>
|-
|[[Chlorine trifluoride]] (ClF<sub>3</sub>)
|mouse, absorption through skin
|178&nbsp;μg/kg
|0.000178
|<ref>{{Cite web |date=2018-11-02 |title=CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Chlorine trifluoride - NIOSH Publications and Products |url=https://www.cdc.gov/niosh/idlh/7790912.html |access-date=2022-07-13 |website=www.cdc.gov |language=en-us |archive-date=2022-07-11 |archive-url=https://web.archive.org/web/20220711073705/https://www.cdc.gov/niosh/idlh/7790912.html |url-status=live }}</ref>
|-
| [[Sarin]]
| mouse, subcutaneous injection
| {{ntsh|.172}}172&nbsp;μg/kg
| 0.000172
| <ref>{{cite journal | vauthors = Inns RH, Tuckwell NJ, Bright JE, Marrs TC | title = Histochemical demonstration of calcium accumulation in muscle fibres after experimental organophosphate poisoning | journal = Human & Experimental Toxicology | volume = 9 | issue = 4 | pages = 245–250 | date = July 1990 | pmid = 2390321 | doi = 10.1177/096032719000900407 | bibcode = 1990HETox...9..245I | s2cid = 20713579 }}</ref>
|-
| [[Robustoxin]] (from [[Sydney funnel-web spider]])
| mice
| {{ntsh|.150}}150&nbsp;μg/kg
| 0.000150
| <ref>{{cite journal | vauthors = Sheumack DD, Baldo BA, Carroll PR, Hampson F, Howden ME, Skorulis A | title = A comparative study of properties and toxic constituents of funnel web spider (Atrax) venoms | journal = Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology | volume = 78 | issue = 1 | pages = 55–68 | year = 1984 | pmid = 6146485 | doi = 10.1016/0742-8413(84)90048-3 }}</ref>
|-
| [[VX (nerve agent)|VX]]
| human, oral, inhalation, absorption through skin/eyes
| {{ntsh|.14}}140&nbsp;μg/kg (estimated)
| 0.00014
| <ref>{{cite journal | vauthors = Munro N | title = Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection | journal = Environmental Health Perspectives | volume = 102 | issue = 1 | pages = 18–38 | date = January 1994 | pmid = 9719666 | pmc = 1567233 | doi = 10.1289/ehp.9410218 | bibcode = 1994EnvHP.102...18M }}</ref>
|-
| Venom of the [[Brazilian wandering spider]]
| rat, subcutaneous
| {{ntsh|.134}}134&nbsp;μg/kg
| 0.000134
| <ref>''Venomous Animals and their Venoms'', vol. III, ed. Wolfgang Bücherl and Eleanor Buckley</ref>
|-
| [[Amatoxin]] (from ''[[Amanita phalloides]]'' mushrooms)
| human, oral
| 100&nbsp;μg/kg
| 0.0001
| <ref>{{cite journal | vauthors = Hallen HE, Luo H, Scott-Craig JS, Walton JD | title = Gene family encoding the major toxins of lethal Amanita mushrooms | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 48 | pages = 19097–19101 | date = November 2007 | pmid = 18025465 | pmc = 2141914 | doi = 10.1073/pnas.0707340104 | doi-access = free }}</ref><ref>{{cite book | vauthors = Madore F, Bouchard J | chapter = Plasmapheresis in Acute Intoxication and Poisoning |date=2019 | title = Critical Care Nephrology |pages=595–600.e3 |publisher=Elsevier |language=en |doi=10.1016/b978-0-323-44942-7.00100-x |isbn=978-0-323-44942-7 }}</ref>
|-
|[[Dimethylmercury]] ({{chem2|Hg(CH3)2}})
|human, transdermal
|{{ntsh|.080}}50&nbsp;μg/kg
|0.000050
|<ref>{{cite journal | vauthors = Blayney MB | title = The need for empirically derived permeation data for personal protective equipment: the death of Dr. Karen E. Wetterhahn | journal = Applied Occupational and Environmental Hygiene | volume = 16 | issue = 2 | pages = 233–236 | date = February 2001 | pmid = 11217716 | doi = 10.1080/104732201460389 }}</ref>
|-
|[[TBPO]] (t-Butyl-bicyclophosphate)
|mouse, intravenous
|36&nbsp;μg/kg
|0.000036
|<ref name="pmid452023">{{cite journal | vauthors = Milbrath DS, Engel JL, Verkade JG, Casida JE | title = Structure--toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes | journal = Toxicology and Applied Pharmacology | volume = 47 | issue = 2 | pages = 287–293 | date = February 1979 | pmid = 452023 | doi = 10.1016/0041-008x(79)90323-5 | bibcode = 1979ToxAP..47..287M }}</ref>
|-
| [[Fentanyl]]
| monkey
| 30&nbsp;μg/kg
| 0.00003
| <ref>{{cite web|url=https://www.drugbank.ca/drugs/DB00813|title=Fentanyl|website=www.drugbank.ca|access-date=2017-09-29|archive-url=https://web.archive.org/web/20170711073330/https://www.drugbank.ca/drugs/DB00813|archive-date=2017-07-11|url-status=dead}}</ref>
|-
| Venom of the [[inland taipan]] 
| rat, subcutaneous
| {{ntsh|.025}}25&nbsp;μg/kg
| 0.000025
| <ref>[http://www.seanthomas.net/oldsite/ld50tot.html LD50 for various snakes] {{webarchive|url=https://web.archive.org/web/20120201062634/http://www.seanthomas.net/oldsite/ld50tot.html |date=2012-02-01 }}. Seanthomas.net. Retrieved on 2013-07-17.</ref>
|-
| [[Ricin]] (from [[castor oil plant]])
| rat, intraperitoneal <br /> rat, oral
| {{ntsh|.022}}22&nbsp;μg/kg <br /> 20–30&nbsp;mg/kg
| 0.000022 <br /> 0.02
| <ref>{{cite journal |title=Ricin (from ''Ricinus communis'') as undesirable substances in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain |journal=EFSA Journal |year=2008 |volume=6 |issue=9 |page=726 |doi=10.2903/j.efsa.2008.726 |citeseerx=10.1.1.333.8413 }}</ref>
|-
| [[2,3,7,8-Tetrachlorodibenzodioxin]] (TCDD, in [[Agent Orange]])
| rat, oral
| {{ntsh|.02}}20&nbsp;μg/kg
| 0.00002
|
|-
| [[Tetrodotoxin]] from the [[blue-ringed octopus]]
| intravenous
| {{ntsh|.0082}}8.2&nbsp;μg/kg
| 0.0000082
| <ref>{{cite journal | vauthors = Knutsen HK, Alexander J, Barregård L, Bignami M, Brüschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Edler L, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald IP, Rose M, Roudot AC, Schwerdtle T, Vleminckx C, Vollmer G, Wallace H, Arnich N, Benford D, Botana L, Viviani B, Arcella D, Binaglia M, Horvath Z, Steinkellner H, van Manen M, Petersen A | title = Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods | journal = EFSA Journal. European Food Safety Authority | volume = 15 | issue = 4 | pages = e04752 | date = April 2017 | pmid = 32625458 | pmc = 7010203 | doi = 10.2903/j.efsa.2017.4752 | s2cid = 54043321 | doi-access = free }}</ref>
|-
| CrTX-A (from ''[[Carybdea rastonii]]'' [[box jellyfish]] [[venom]])
| crayfish, intraperitoneal
| {{ntsh|.005}}5&nbsp;μg/kg
| 0.000005
| <ref>{{cite journal | vauthors = Nagai H |title=Recent Progress in Jellyfish Toxin Study |journal=Journal of Health Science |date=2003 |volume=49 |issue=5 |pages=337–340 |doi=10.1248/jhs.49.337 |doi-access=free }}</ref>
|-
| [[Latrotoxin]] (from [[Latrodectus|widow spider]] [[venom]])
| mice
| {{ntsh|.0043}}4.3&nbsp;μg/kg
| 0.0000043
| <ref>{{Cite web |url=http://biology.unm.edu/toolson/biotox/presentations_2013/ALPHA-LATROTOXIN%20POWERPOINT.pptx |title=Black Widow Venom (α-Latrotoxin) | vauthors = Henderson N, Wright K, Morgan D, Tantum P |format=pptx |access-date=2016-12-26 |archive-url=https://web.archive.org/web/20161226221309/http://biology.unm.edu/toolson/biotox/presentations_2013/ALPHA-LATROTOXIN%20POWERPOINT.pptx |archive-date=2016-12-26 |url-status=dead }}</ref>{{self-published inline|date=December 2020}}
|-
|[[Epibatidine]] (from ''[[Epipedobates anthonyi]]'' poison dart frog)
|mouse, intravenous
|1.46-13.98&nbsp;μg/kg
|0.00000146
|<ref>{{cite journal | vauthors = Sihver W, Långström B, Nordberg A | title = Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain | journal = Acta Neurologica Scandinavica. Supplementum | volume = 176 | issue = s176 | pages = 27–33 | date = 2000 | pmid = 11261802 | doi = 10.1034/j.1600-0404.2000.00304.x | s2cid = 23541883 | doi-access = free }}</ref>
|-
| [[Batrachotoxin]] (from [[poison dart frog]])
| human, sub-cutaneous injection
| {{ntsh|.002}}2–7&nbsp;μg/kg (estimated)
| 0.000002
| <ref name=":0">{{cite journal | vauthors = Patocka J, Streda L |year=2002 |title=Brief review of natural nonprotein neurotoxins |journal=ASA Newsletter |volume=2 |issue=2 |pages=16–24 }}</ref>
|-
|[[Abrin]] (from [[rosary pea]])
|mice, intravenously<br>human, inhalation<br>human, oral 
|0.7&nbsp;μg/kg<br>3.3&nbsp;μg/kg<br>10–1000&nbsp;μg/kg 
|0.0000007<br>0.0000033<br>0.00001–0.001
|{{Citation needed|date=June 2024}}
|-
|[[Saxitoxin]] (from certain marine [[dinoflagellate]]s)
|human, intravenously<br>human, oral
|0.6&nbsp;μg/kg<br>5.7&nbsp;μg/kg
|0.0000006<br>0.0000057
|<ref name=":0" />
|-
| Pacific [[ciguatoxin]]-1 (from [[Ciguatera|ciguateric fish]])
| mice, intraperitoneal
| 250&nbsp;ng{{ntsh|.00025}}/kg
| 0.00000025
|<ref>{{cite journal | vauthors = Caillaud A, de la Iglesia P, Darius HT, Pauillac S, Aligizaki K, Fraga S, Chinain M, Diogène J | title = Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe | journal = Marine Drugs | volume = 8 | issue = 6 | pages = 1838–1907 | date = June 2010 | pmid = 20631873 | pmc = 2901828 | doi = 10.3390/md8061838 | doi-access = free }}</ref>
|-
|[[Palytoxin]] (from ''[[Palythoa]]'' coral)
|mouse, intravenous<br>{{Fix|text=What do the 2 different figures represent?}}
|45&nbsp;ng/kg<br>2.3–31.5&nbsp;μg/kg
|0.000000045<br>0.0000023
|<ref>{{cite journal | vauthors = Ramos V, Vasconcelos V | title = Palytoxin and analogs: biological and ecological effects | journal = Marine Drugs | volume = 8 | issue = 7 | pages = 2021–2037 | date = June 2010 | pmid = 20714422 | pmc = 2920541 | doi = 10.3390/md8072021 | doi-access = free }}</ref>
|-
| [[Maitotoxin]] (from [[Ciguatera|ciguateric fish]])
| mouse, [[intraperitoneal]]
| 50&nbsp;ng{{ntsh|.00005}}/kg
| 0.00000005
|<ref>{{cite web | url=https://pubchem.ncbi.nlm.nih.gov/compound/maitotoxin | publisher=[[National Center for Biotechnology Information]] | title=PubChem Compound Summary for CID 71460273, Maitotoxin | work=[[PubChem]] | access-date=2020-12-25 | archive-date=2020-11-01 | archive-url=https://web.archive.org/web/20201101135722/https://pubchem.ncbi.nlm.nih.gov/compound/Maitotoxin | url-status=live }}</ref>
|-
| [[Polonium-210]] ({{chem|210|Po}})
| human<!-- double check reference -->, inhalation
| {{ntsh|.00001}}10&nbsp;ng/kg (estimated)
| 0.00000001
| <ref>[http://agrippina.deakin.edu.au/occ-hyg/sbc312/sbc312-07/SBC312-Topic2-07.htm Topic 2 Toxic Chemicals and Toxic Effects] {{webarchive|url=https://web.archive.org/web/20070929131217/http://agrippina.deakin.edu.au/occ-hyg/sbc312/sbc312-07/SBC312-Topic2-07.htm |date=2007-09-29 }}</ref>
|-
| [[Diphtheria toxin]] (from ''[[Corynebacterium]]'')
| mice
| {{ntsh|.00001}}10&nbsp;ng/kg
| 0.00000001
| <ref name="biology.unm.edu">{{Cite web |url=http://biology.unm.edu/toolson/biotox/representative_LD50_values.pdf |title=Representative LD<sub>50</sub> Values | vauthors = Toolson E |access-date=2016-12-26 |archive-url=https://web.archive.org/web/20150412045434/http://biology.unm.edu/toolson/biotox/representative_LD50_values.pdf |archive-date=2015-04-12 |url-status=dead }}</ref>
|-
| [[Shiga toxin]] (from ''[[Shigella]]'' bacteria)
| mice
| {{ntsh|.000002}}2&nbsp;ng/kg
| 0.000000002
| <ref name="biology.unm.edu"/>
|-
| [[Tetanospasmin]] (from ''[[Clostridium tetani]]'')
| mice
| {{ntsh|.000002}}2&nbsp;ng/kg
| 0.000000002
| <ref name="biology.unm.edu"/>
|-
| [[Botulinum toxin]] (from ''[[Clostridium botulinum]]'')
| human, oral, injection, inhalation
| {{ntsh|.000001}}1&nbsp;ng/kg (estimated)
| 0.000000001
| <ref>{{cite book | vauthors = Fleming DO, Hunt DL |title=Biological Safety: principles and practices |publisher=ASM Press |location=Washington, DC |year=2000 |page=[https://archive.org/details/biologicalsafety0000unse_3rdedition/page/267 267] |isbn=978-1-55581-180-8 |url=https://archive.org/details/biologicalsafety0000unse_3rdedition/page/267 }}</ref>
|-
| [[Ionizing radiation]]
| human, irradiation
| 3–5&nbsp;[[Gray (unit)|Gy]] (Gray)
| —
|<ref>{{cite journal | vauthors = Ryan JL | title = Ionizing radiation: the good, the bad, and the ugly | journal = The Journal of Investigative Dermatology | volume = 132 | issue = 3 Pt 2 | pages = 985–993 | date = March 2012 | pmid = 22217743 | pmc = 3779131 | doi = 10.1038/jid.2011.411 }}</ref><ref>{{cite web |date=2013 |title=Lethal dose |url=https://www.euronuclear.org/info/encyclopedia/l/lethal-dose.htm |url-status=dead |archive-url=https://web.archive.org/web/20180804014252/https://www.euronuclear.org/info/encyclopedia/l/lethal-dose.htm |archive-date=2018-08-04 |access-date=2018-09-15 |website=www.euronuclear.org |vauthors=Winfried K}}</ref><ref>{{Cite web |date=2022-12-13 |title=Radiation Exposure - Dose and Dose Rate (the Gray & Sievert) |url=https://ionactive.co.uk/resource-hub/guidance/radiation-exposure-dose-and-dose-rate-the-gray-sievert |access-date=2024-07-27 |website=Ionactive}}</ref>
|}