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Mevalonate pathway
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==Regulation and feedback== Several key [[enzymes]] can be activated through [[DNA transcription]]al regulation on activation of [[SREBP]] (sterol regulatory element-binding protein-1 and -2). This intracellular sensor detects low [[cholesterol]] levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing [[lipoprotein]] uptake by up-regulating the [[LDL receptor|LDL-receptor]]. Regulation of this pathway is also achieved by controlling the rate of translation of the mRNA, degradation of reductase and phosphorylation.<ref name="GENERAL"/>
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