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===In video games=== [[File:Mega Mewtwo Forms.png|thumb|Mewtwo has two Mega Evolutions, Mega Mewtwo X (left) and Mega Mewtwo Y (right).]] In ''Pokémon Red'' and ''Blue'', the player learns of Mewtwo's existence by reading research notes left in the ruined Pokémon Mansion on Cinnabar Island. The notes say that a scientist{{ref|a}} discovered a new Pokémon in a [[Guyana]] jungle, that they named it Mew, and that it later gave birth to a creature they called Mewtwo; the game's Pokédex entry states that Mewtwo was "created by a scientist after years of horrific gene splicing and DNA engineering experiments".<ref name="trophy1">{{cite video game |title=[[Super Smash Bros. Melee]] |developer=Nintendo |publisher=Nintendo |date=December 3, 2001 |level=Mewtwo Trophy #1 description |quote=A genetically created Pokémon, Mewtwo is the result of many long years of research by a solitary scientist. Although Mewtwo was "cloned" from the genes of the legendary Pokémon Mew, its size and characteristics are far different from its ancestor. Its battle abilities have been radically heightened, making it ruthless.}}</ref><ref>{{cite video game |title=[[Pokémon Red and Blue|Pokémon Red]] |developer=[[Game Freak]] |publisher=Nintendo |date=September 30, 1998 |level=Pokémon Mansion, Cinnibar Island |quote=Feb. 6. MEW gave birth. We named the newborn MEWTWO.}}</ref> Mewtwo proved too mighty to control, destroying the laboratory and escaping. The player is later given an opportunity to capture Mewtwo in the Cerulean Cave, which is accessible only after defeating the game's final [[boss (video games)|bosses]], the [[Elite Four]] and [[Blue (Pokémon character)|Blue]];<ref>{{cite book |author=Rich, Jason |year=1999 |title=Pokémon: Pathways to Adventure |publisher=[[Sybex]] |page=[https://archive.org/details/pokemonpathwayst00jaso_0/page/101 101] |isbn=978-0-7821-2503-0 |url=https://archive.org/details/pokemonpathwayst00jaso_0/page/101 }}</ref> in the remakes [[Pokémon FireRed and LeafGreen|''Pokémon FireRed'' and ''LeafGreen'']] this prerequisite was expanded, requiring the player to explore more thoroughly and record information on sixty Pokémon species before access to the cave would be granted.<ref>{{cite book |author=Nintendo staff |year=2004 |title=Pokémon Leafgreen Version, Firered Version the Official Nintendo Player's Guide |publisher=Nintendo |isbn=978-1-930206-50-2}}</ref> Mewtwo can be caught in [[Pokémon HeartGold and SoulSilver|''Pokémon HeartGold'' and ''SoulSilver'']] in the same location as before after defeating all of the gym leaders in Kanto. The character was also the focus of a promotion and [[downloadable content]] giveaway for [[Pokémon Black and White|''Pokémon Black'' and ''White'']], debuting with its signature move "Psystrike" that can also be learned by leveling up.<ref>{{cite web| title=The Legend of Mewtwo Continues| url=http://www.pokemon.com/us/ex/mewtwo| access-date=2012-03-11| publisher=The Pokémon Company International| archive-url=https://web.archive.org/web/20120308163314/http://www.pokemon.com/us/ex/mewtwo| archive-date=2012-03-08}}</ref><ref>{{Cite web |last=Drake |first=Audrey |date=2012-02-06 |title=Catch Mewtwo in Pokemon Black and White! |url=https://www.ign.com/articles/2012/02/06/catch-mewtwo-in-pokemon-black-and-white |access-date=2024-05-21 |website=IGN |language=en}}</ref> Mewtwo also reappears in [[Pokémon X and Y|''Pokémon X'' and ''Y'']] after completing the main story, and is one of the handful of Pokémon capable of using the new Mega Evolution mechanic, as it can transform into either Mega Mewtwo X or Mega Mewtwo Y.<ref>{{cite web |url=http://www.pokemonxy.com/en-us/pokemon/mega_pokemon/ |title=Mega Pokémon |publisher=Pokemonxy.com |access-date=2013-08-09 |archive-date=2015-04-05 |archive-url=https://web.archive.org/web/20150405083910/http://www.pokemonxy.com/en-us/pokemon/mega_pokemon/ |url-status=live }}</ref><ref>{{cite web |url=http://www.pokemon.co.jp/ex/xy/pokemon/mega/01.html |title=メガミュウツー|『ポケットモンスター エックス』『ポケットモンスター ワイ』公式サイト |publisher=Pokemon.co.jp |access-date=2013-08-09 |archive-date=2013-08-13 |archive-url=https://web.archive.org/web/20130813011416/http://www.pokemon.co.jp/ex/xy/pokemon/mega/01.html |url-status=live }}</ref> Mewtwo reappears in [[Pokémon: Let's Go, Pikachu! and Let's Go, Eevee!]], another remake of ''Red and Blue'', again in Cerulean Cave and is capable of Mega Evolution.<ref>{{Cite news |date=2019-03-08 |title=Pokémon Let's Go Cerulean Cave and how to find Mewtwo - available Pokémon, items and trainers |url=https://www.eurogamer.net/pokemon-lets-go-walkthrough-guide-5010?page=49 |access-date=2024-05-21 |work=Eurogamer.net |language=en}}</ref><ref>{{Cite web |last=Cooper |first=Dalton |date=2018-11-23 |title=Pokemon Let's Go: How to Get Mega Stones |url=https://gamerant.com/pokemon-lets-go-mega-stone/ |access-date=2024-05-21 |website=Game Rant |language=en}}</ref> Mewtwo is also obtainable alongside other past Legendary Pokémon in [[Pokémon Ultra Sun and Ultra Moon]],<ref>{{Cite web |last1=Koczwara |first1=Michael |last2=Professor_oak |last3=DeFreitas |first3=Casey |last4=Moreupdated |first4=+11 0k |date=2017-11-17 |title=Ultra Wormholes - Pokemon Sun & Pokemon Moon Guide |url=https://www.ign.com/wikis/pokemon-sun-pokemon-moon/Ultra_Wormholes |access-date=2024-05-21 |website=IGN |language=en}}</ref><ref>{{Cite web |date=2017-11-02 |title='Pokémon Ultra Sun' and 'Moon' Will Let You Catch Every Legendary Pokémon |url=https://www.inverse.com/article/38060-pokemon-ultra-sun-ultra-moon-version-specific-legendary-legendaries |access-date=2024-05-21 |website=Inverse |language=en}}</ref> [[Pokémon Sword and Shield: The Crown Tundra]],<ref>{{Cite web |last=Chan |first=Daniel |date=2020-10-29 |title=Pokemon Sword & Shield: All Catchable Legendaries In Dynamax Adventures |url=https://gamerant.com/pokemon-sword-shield-legendary-dynamax-adventure/ |access-date=2024-05-21 |website=Game Rant |language=en}}</ref> and [[Pokémon Brilliant Diamond and Shining Pearl]].<ref>{{Cite web |last=Bowen |first=Tom |date=2021-11-28 |title=Pokemon Brilliant Diamond & Shining Pearl: Where to Find and Catch Mewtwo |url=https://gamerant.com/pokemon-brilliant-diamond-shining-pearl-how-to-catch-mewtwo-location/ |access-date=2024-05-21 |website=Game Rant |language=en}}</ref><ref>{{Cite web |title=Pokemon Brilliant Diamond and Shining Pearl add a way to get older legendaries |url=https://www.cnet.com/tech/gaming/brilliant-diamond-and-shining-pearl-add-a-way-to-get-older-legendary-pokemon/ |access-date=2024-05-21 |website=CNET |language=en}}</ref> In addition to being transferable to almost every mainline ''Pokémon'' game, Mewtwo has also made appearances in multiple spin-offs. In ''[[Pokémon Stadium]]'' and ''[[Pokémon Pinball]]'', Mewtwo appears as a final boss after all competitions have been completed.<ref>{{cite book |title=Pokémon Stadium: Prima's Official Strategy Guide |last=Barton |first=Jeff |year=2000 |publisher=[[Prima Games]] |isbn=978-0-7615-2278-2 |page=73}}</ref><ref>{{cite web |script-title=ja:極めれば達人になれるニャー! |url=https://www.nintendo.co.jp/n02/dmg/vphj/high/page04.html |access-date=2009-06-06 |publisher=Nintendo |language=ja |archive-date=2009-10-15 |archive-url=https://web.archive.org/web/20091015045907/http://www.nintendo.co.jp/n02/dmg/vphj/high/page04.html |url-status=live }}</ref> In ''[[Pokémon Puzzle League]]'', Mewtwo, voiced by [[Philip Bartlett]], serves not only as the final opponent, but also as the main [[antagonist]] responsible for the game's events.<ref>{{cite video game|title=[[Pokémon Puzzle League]] |developer=[[Nintendo Software Technology]]/[[Intelligent Systems]] |publisher=Nintendo |date=2000-09-25 |platform=[[Nintendo 64]] |level=Mewtwo stage |quote='''Mewtwo''': Welcome, Puzzle champion. I am the Puzzle Master. I doubt you have what it takes to defeat me. It is my destiny to crush all who oppose me.}}</ref> Mewtwo appears in the ''[[Pokémon Mystery Dungeon: Blue Rescue Team and Red Rescue Team|Pokémon Mystery Dungeon]]'' series, featuring Mewtwo as an unlockable [[player character]] that must be defeated before it may be used in ''[[Pokémon Mystery Dungeon: Blue Rescue Team and Red Rescue Team]].''<ref>{{cite book |title=Pokémon Mystery Dungeon: Blue Rescue Team, Red Rescue Team: The Official Nintendo Player's Guide |publisher=[[Nintendo of America]] |location=Redmond, Washington |author=Staff |year=2006 |isbn=978-1-59812-010-3 |url=https://archive.org/details/pokemonmysterydu0000loec }}</ref> Mewtwo has been a playable character in multiple entries of the ''[[Super Smash Bros.]]'' series. Mewtwo was originally meant to appear in the original [[Super Smash Bros. (video game)|''Super Smash Bros.'']], but was cut due to time constraints.<ref>{{Cite web |last=Fontes |first=Renan |date=2020-05-30 |title=Super Smash Bros. 64: Every Character Cut From The Roster |url=https://gamerant.com/super-smash-bros-64-every-character-cut/ |access-date=2024-05-20 |website=Game Rant |language=en}}</ref> Mewtwo made its debut in the series in ''[[Super Smash Bros. Melee]]'' voiced by Masachika Ichimura who reprises his role in ''[[Pokémon: The First Movie]]''. After simply appearing as a trophy ''[[Super Smash Bros. Brawl]]'', Mewtwo returned to the series as a [[Downloadable content|DLC]] character in ''Super Smash Bros. for Nintendo 3DS'' and ''Wii U'' on April 28, 2015, though it was made available to Club Nintendo members who registered both versions on April 15, 2015. In ''3DS'' and ''Wii U'', its Final Smash involves it Mega Evolving into Mega Mewtwo Y and using Psystrike, its signature move in the ''Pokémon'' games.<ref>{{cite web|url=https://www.independent.co.uk/life-style/gadgets-and-tech/gaming/super-smash-bros-wii-u-gets-mewtwo-and-53-other-new-details-9816460.html |archive-url=https://ghostarchive.org/archive/20220512/https://www.independent.co.uk/life-style/gadgets-and-tech/gaming/super-smash-bros-wii-u-gets-mewtwo-and-53-other-new-details-9816460.html |archive-date=2022-05-12 |url-access=subscription |url-status=live|work=[[The Independent]]|access-date=October 27, 2014|date=October 24, 2014|title=Super Smash Bros Wii U gets Mewtwo and 53 other new details|author=Hooton, Christopher}}</ref> Mewtwo also returned as a playable character in ''[[Super Smash Bros. Ultimate]]'' for the [[Nintendo Switch]], where it is once again an unlockable character.<ref>{{cite web |url=https://www.usgamer.net/articles/super-smash-bros-ultimate-switch-every-playable-hero-revealed |archive-url=https://web.archive.org/web/20180612192151/https://www.usgamer.net/articles/super-smash-bros-ultimate-switch-every-playable-hero-revealed |title=Super Smash Bros Ultimate on Switch Will Have Every Smash Hero Ever, Release Date Announced |last=Kim |first=Matt |website=[[USGamer]] |date=12 June 2018 |access-date=12 June 2018 |archive-date=12 June 2018 |quote=That means fan favorite characters like Roy, Mewtwo, and even Snake are back for Super Smash Bros. Ultimate. }}</ref> In both ''3DS/Wii U'' and ''Ultimate'', [[Keiji Fujiwara]] voices Mewtwo in all languages.<ref>{{Cite web |title=Wii U/3DS「大乱闘スマッシュブラザーズ」の更新データ(Ver. 1.0.6)の配信が本日スタート。先行配信の始まったミュウツーの声は藤原啓治さん |url=https://www.4gamer.net/games/134/G013467/20150415091/ |url-status=live |archive-url=https://web.archive.org/web/20210709183855/https://www.4gamer.net/games/134/G013467/20150415091/ |archive-date=2021-07-09 |access-date=2021-07-06 |website=www.4gamer.net}}</ref> A new form of Mewtwo, Shadow Mewtwo, appears as a boss character in ''[[Pokkén Tournament]]''<ref>{{cite web|url=https://www.youtube.com/watch?v=aJRtBiFD144 |archive-url=https://ghostarchive.org/varchive/youtube/20211211/aJRtBiFD144| archive-date=2021-12-11 |url-status=live|title=Shadow Mewtwo Revealed in Pokkén Tournament!|last=pokemon|date=3 November 2015|via=YouTube}}{{cbignore}}</ref> and has a special attack that involves it Mega Evolving into Mega Mewtwo X. Shadow Mewtwo can also be unlocked as a playable character. In addition, its normal form appears as a playable character.<ref>{{Cite web|url=https://www.destructoid.com/three-new-pokemon-confirmed-for-pokken-tournament/|title=Three new Pokemon confirmed for Pokken Tournament|date=January 13, 2016|access-date=July 6, 2021|archive-date=June 20, 2021|archive-url=https://web.archive.org/web/20210620045727/https://www.destructoid.com/three-new-pokemon-confirmed-for-pokken-tournament/|url-status=live}}</ref> In augmented reality mobile game ''[[Pokémon Go]]'', Mewtwo is able to be battled and caught in event Raids available on select dates and times,<ref>{{Cite web |title=Mewtwo Pokémon GO Raid Battle Tips |url=https://www.pokemon.com/us/strategy/mewtwo-pokemon-go-raid-battle-tips |access-date=2024-05-20 |website=www.pokemon.com |language=en}}</ref> including a different variation of Mewtwo wearing its armor from ''[[Pokémon: Mewtwo Strikes Back – Evolution|Pokémon: Mewtwo Strikes Back - Evolution]]'' that was made available for a limited time in Tier 5 Raids in July 2019.<ref>{{Cite web|url=https://www.eurogamer.net/articles/2019-06-19-pokemon-go-raid-hour-raid-battles-raid-passes-raid-rewards-4819|title=Pokémon Go Raid Hour date and time, plus how Raids work, including Raid Rewards and Raid level requirement|first=Matthew|last=Reynolds|website=[[Eurogamer]]|date=September 2, 2020|access-date=2019-07-24|archive-date=2019-07-17|archive-url=https://web.archive.org/web/20190717110037/https://www.eurogamer.net/articles/2019-06-19-pokemon-go-raid-hour-raid-battles-raid-passes-raid-rewards-4819|url-status=live}}</ref><ref>{{Cite web|url=https://pokemongolive.com/post/armoredmewtworaids2019/|title=Harness the power of Armored Mewtwo!|website=Pokémon GO|access-date=2021-07-06|archive-date=2024-01-28|archive-url=https://web.archive.org/web/20240128163304/https://pokemongolive.com/post/armoredmewtworaids2019/|url-status=live}}</ref><ref>{{Cite web|url=https://www.forbes.com/sites/paultassi/2019/07/06/armored-mewtwo-is-coming-to-pokemon-go-in-new-raid-battles-soon/|title=Armored Mewtwo Is Coming To 'Pokemon GO' In New Raid Battles Soon|first=Paul|last=Tassi|website=Forbes|access-date=2019-07-24|archive-date=2019-07-24|archive-url=https://web.archive.org/web/20190724083141/https://www.forbes.com/sites/paultassi/2019/07/06/armored-mewtwo-is-coming-to-pokemon-go-in-new-raid-battles-soon/|url-status=live}}</ref> In the [[Detective Pikachu (video game)|''Detective Pikachu'']] game and its sequel ''[[Detective Pikachu Returns]]'', Mewtwo is a major character of the plot with it being a key to the mystery behind the disappearance of the main character's father, Harry Goodman.<ref>{{Cite web |last1=Randell |first1=Laura May |last2=Cotten |first2=Shailyn |last3=Sanchez |first3=Miranda |display-authors=etal |date=2023-10-12 |title=Detective Pikachu Returns Ending Explained - Detective Pikachu Returns Guide |url=https://www.ign.com/wikis/detective-pikachu-returns/Detective_Pikachu_Returns_Ending_Explained |access-date=2024-05-20 |website=IGN |language=en}}</ref> Mewtwo also appears as a usable Pokémon in [[Pokémon Masters]] as the partner of Giovanni, who first became playable in the first Legendary Event, "Lurking Shadow". During the first part of the Villain Arc story with [[Team Rocket]], "Looming Shadow of Kanto", the player could obtain Giovanni Legendary Spirit to raise the rarity of Giovanni to 6-Star EX if the player also used all 20 Power-Ups for Giovanni, which gives it a power boost and makes his Sync Move target all opponents instead of one, and then in the second part of the arc, "Spreading Shadow", the player could obtain Mewtwo Crystals to allow Giovanni's Mewtwo to evolve into Mega Mewtwo Y, which makes it even stronger and replaces the move Confusion with Psystrike until the end of the battle.{{citation needed|date=May 2024}} In July 2023, Mewtwo was added as a playable character to ''[[Pokémon Unite]]''.<ref>{{cite web | url=https://www.destructoid.com/a-wild-mewtwo-appears-in-pokemon-unite/ | title=A wild Mewtwo appears in Pokemon Unite | date=21 July 2023 }}</ref>
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