Editing Micronization (section)

=== RESS ===
In the case of RESS (Rapid Expansion of Supercritical Solutions), the supercritical fluid is used to [[Solvation|dissolve]] the solid material under high pressure and temperature, thus forming a [[Homogeneity and heterogeneity|homogeneous]] supercritical [[Phase (matter)|phase]]. Thereafter, the [[mixture]] is expanded through a nozzle to form the smaller particles. Immediately upon exiting the nozzle, rapid expansion occurs, lowering the pressure. The pressure will drop below supercritical pressure, causing the supercritical fluid - usually [[carbon dioxide]] - to return to the [[gas]] state. This phase change severely decreases the solubility of the mixture and results in precipitation of particles.<ref>{{Cite journal|last1=Fattahi|first1=Alborz|last2=Karimi-Sabet|first2=Javad|last3=Keshavarz|first3=Ali|last4=Golzary|first4=Abooali|last5=Rafiee-Tehrani|first5=Morteza|last6=Dorkoosh|first6=Farid A.|date=2016-01-01|title=Preparation and characterization of simvastatin nanoparticles using rapid expansion of supercritical solution (RESS) with trifluoromethane|journal=The Journal of Supercritical Fluids|volume=107|pages=469–478|doi=10.1016/j.supflu.2015.05.013}}</ref> The less time it takes the solution to expand and the solute to precipitate, the narrower the particle size distribution will be. Faster precipitation times also tend to result in smaller particle diameters.<ref name=":3">{{Cite journal|last1=Hezave|first1=Ali Zeinolabedini|last2=Aftab|first2=Sarah|last3=Esmaeilzadeh|first3=Feridun|date=2010-11-01|title=Micronization of creatine monohydrate via Rapid Expansion of Supercritical Solution (RESS)|journal=The Journal of Supercritical Fluids|volume=55|issue=1|pages=316–324|doi=10.1016/j.supflu.2010.05.009}}</ref>