Editing Microtome (section)

===Precision cut kidney slices===
'''Precision-cut kidney slices''' refer to thin sections of the kidney tissue that are prepared using a microtome to study kidney functions, drug metabolism or disease processes. Researchers use these slices to study the impact of substances on renal function.<ref>{{Cite journal |last1=Poosti |first1=Fariba |last2=Pham |first2=Bao Tung |last3=Oosterhuis |first3=Dorenda |last4=Poelstra |first4=Klaas |last5=van Goor |first5=Harry |last6=Olinga |first6=Peter |last7=Hillebrands |first7=Jan-Luuk |date=2015-01-01 |title=Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ''ex vivo'' |url=http://dx.doi.org/10.1242/dmm.020172 |journal=Disease Models & Mechanisms |volume=8 |issue=10 |pages=1227–1236 |doi=10.1242/dmm.020172 |pmid=26112172 |pmc=4610232 |issn=1754-8411}}</ref><ref>{{cite journal | doi=10.4137/BMI.S38439 | title=Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis | date=2016 | last1=Genovese | first1=Federica | last2=Kàrpàti | first2=Zsolt S. | last3=Nielsen | first3=Signe H. | last4=Karsdal | first4=Morten A. | journal=Biomarker Insights | volume=11 | pages=77–84 | pmid=27257368 | pmc=4877083 }}</ref> This includes drug metabolism<ref>{{cite journal | url=https://www.tandfonline.com/doi/abs/10.1517/17425255.3.6.879 | doi=10.1517/17425255.3.6.879 | title=Precision-cut tissue slices as a tool to predict metabolism of novel drugs | date=2007 | last1=Graaf | first1=Inge AM de | last2=Groothuis | first2=Geny MM | last3=Olinga | first3=Peter | journal=Expert Opinion on Drug Metabolism & Toxicology | volume=3 | issue=6 | pages=879–898 | pmid=18028031 | s2cid=36518505 | url-access=subscription }}</ref><ref>{{cite journal | url=https://www.sciencedirect.com/science/article/abs/pii/S0887233399000478 | doi=10.1016/S0887-2333(99)00047-8 | title=Organ Slices as an in Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney | date=1999 | last1=De Kanter | first1=R. | last2=Olinga | first2=P. | last3=De Jager | first3=M.H | last4=Merema | first4=M.T | last5=Meijer | first5=D.K.F | last6=Groothius | first6=G.M.M | journal=Toxicology in Vitro | volume=13 | issue=4–5 | pages=737–744 | pmid=20654543 | url-access=subscription }}</ref> and the effects of toxic substances.<ref>{{cite journal | url=https://www.sciencedirect.com/science/article/abs/pii/002432059502176J | doi=10.1016/0024-3205(95)02176-J | title=Precision-cut tissue slices: Applications in pharmacology and toxicology | date=1995 | last1=Parrish | first1=Alan R. | last2=Gandolfi | first2=A.Jay | last3=Brendel | first3=Klaus | journal=Life Sciences | volume=57 | issue=21 | pages=1887–1901 | pmid=7475939 | url-access=subscription }}</ref>