Editing Necrotizing fasciitis (section)

===Risk factors===
Vulnerable populations are typically older with medical comorbidities such as diabetes mellitus, obesity, and immunodeficiency.<ref name="Paz2014" />  Other documented risk factors include:

* Any trauma or lacerations
* Injection drug use
* Recent surgery
* Injury of mucous membranes, including hemorrhoids, rectal fissures
* Peripheral artery disease
* Cancer
* Alcohol use disorder
* Pregnancy or recent childbirth<ref name=":5" />

For reasons that are unclear, it can also infect healthy individuals with no previous medical history or injury.<ref name=":5" /><ref>{{cite journal |vauthors= Pricop M, Urechescu H, Sîrbu A, Urtilă E |title= Fasceita necrozantă cervico-toracică: caz clinic și recenzie a literaturii de specialitate |trans-title= Necrotizing cervical fasciitis: clinical case and review of literature |language= ro |journal= Revista de Chirurgie Oro-Maxilo-Facială și Implantologie |issn= 2069-3850 |volume= 2 |issue= 1 |pages= 1–6 |date= Mar 2011 |url= http://www.revistaomf.ro/(1)Colectia-pe-ani/(15)Anul-2011/(16)Numarul-1-2011/(17)Fasceita-necrozanta-cervico-toracica-caz-clinic-si-recenzie-a-literaturii-de-specialitate |url-status= dead |archive-url= https://web.archive.org/web/20160322050522/http://www.revistaomf.ro/(1)Colectia-pe-ani/(15)Anul-2011/(16)Numarul-1-2011/(17)Fasceita-necrozanta-cervico-toracica-caz-clinic-si-recenzie-a-literaturii-de-specialitate |archive-date= 2016-03-22 |access-date= 2016-04-07 }}</ref>

[[Non-steroidal anti-inflammatory drug|NSAIDs]] may increase the rates of necrotizing infections by impairing the body's immune response. NSAIDs inhibit the production of [[Prostaglandin E2|prostaglandins]] responsible for fever, inflammation, and pain. In theory, it also prevents [[Leukocyte extravasation|white blood cells from migrating to infected areas]], thus increasing the risk of soft-tissue infections.<ref name="Hak2014" /><ref name=":5" />

Skin infections such as abscesses and ulcers can also complicate NF. A small percentage of people can also get NF when bacteria from [[streptococcal pharyngitis]] spreads through the blood.<ref name=":6">{{Cite journal |last=Olsen |first=Randall J. |last2=Musser |first2=James M. |date=2010-01-01 |title=Molecular Pathogenesis of Necrotizing Fasciitis |url=https://www.annualreviews.org/doi/10.1146/annurev-pathol-121808-102135 |journal=Annual Review of Pathology: Mechanisms of Disease |language=en |volume=5 |issue=1 |pages=1–31 |doi=10.1146/annurev-pathol-121808-102135 |issn=1553-4006|url-access=subscription }}</ref> For infection of the perineum and genitals ([[Fournier gangrene]]), [[urinary tract infection]], [[Kidney stone disease|renal stones]], and [[Bartholin gland]] abscess may also be implicated.<ref name="Hak2014" />