Editing Neuroendocrine cell (section)

=== Function ===
PNECs may play a role with chemoreceptors in [[hypoxia (medical)|hypoxia]] detection. This is best supported by the presence of an oxygen-sensitive potassium channel coupled to an oxygen sensory protein in the rabbit lumenal membrane. They are hypothetically involved in regulating localized epithelial cell growth and regeneration through a [[Paracrine signalling|paracrine mechanism]], whereby their signaling peptides are released into the environment.  In addition, they contain neuroactive substances which are released from basal cytoplasm. These substances induce autonomic nerve terminals or vasculature in the deep [[lamina propria]].