Editing Nonsense mutation (section)

=== Deleterious ===
Deleterious outcomes represent the majority of nonsense mutations and are the most common outcome that is observed naturally. Deleterious nonsense mutations decreases the overall [[Fitness (biology)|fitness]] and [[reproductive success]] of the [[organism]].<ref name=":4">{{Cite web |date=2018-08-26 |title=Nonsense Mutation — Definition, Example, Outcomes |url=https://biologydictionary.net/nonsense-mutation/ |access-date=2022-12-02 |website=Biology Dictionary |language=en-US}}</ref> For example, a nonsense mutation occurring in a [[gene]] encoding a protein can cause structural or functional defects in the protein that disrupt [[Cell biology|cellular biology.]] Depending on the significance of the functions of this protein, this disruption now could be detrimental to the fitness and survival of that organism.<ref name=":4" />