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Open reading frame
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==Six-frame translation== Since DNA is interpreted in groups of three nucleotides (codons), a DNA strand has three distinct reading frames.<ref name=":0">{{cite journal | vauthors = Pearson WR, Wood T, Zhang Z, Miller W | title = Comparison of DNA sequences with protein sequences | journal = Genomics | volume = 46 | issue = 1 | pages = 24β36 | date = November 1997 | pmid = 9403055 | doi = 10.1006/geno.1997.4995 | s2cid = 6413018 }}</ref> The double helix of a DNA molecule has two anti-parallel strands; with the two strands having three reading frames each, there are six possible frame translations.<ref name=":0" /> [[File:Open reading frame.jpg|thumb|440x440px|Example of a six-frame translation. The nucleotide sequence is shown in the middle with forward translations above and reverse translations below. Two possible open reading frames with the sequences are highlighted.|alt=]]
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