Editing Pemetrexed (section)

===Supplementation===
Patients are recommended to take [[folic acid]] and [[vitamin B12|vitamin B<sub>12</sub>]] supplement even if levels are normal when they are on pemetrexed therapy.<ref>{{cite journal | vauthors = Hazarika M, White RM, Johnson JR, Pazdur R | title = FDA drug approval summaries: pemetrexed (Alimta) | journal = The Oncologist | volume = 9 | issue = 5 | pages = 482–488 | year = 2004 | pmid = 15477632 | doi = 10.1634/theoncologist.9-5-482 | s2cid = 11444611 }}</ref><ref name="Alimta FDA label">{{cite web | title=Alimta- pemetrexed disodium injection, powder, lyophilized, for solution | website=DailyMed | date=25 March 2020 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08 | access-date=20 October 2020 | archive-date=20 October 2020 | archive-url=https://web.archive.org/web/20201020074626/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08 | url-status=live }}</ref> (In clinical trials for mesothelioma, folic acid and B12 supplementation reduced the frequency of adverse events.)  It is also recommended for patients to be on a [[glucocorticoid]] (e.g. [[dexamethasone]]) on the day prior, day of, and day after pemetrexed infusion to avoid skin rashes.<ref name="Alimta FDA label" />