Editing Pethidine (section)

== Interactions ==

Pethidine has serious interactions that can be dangerous with monoamine oxidase inhibitors (e.g., furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). Such patients may suffer agitation, delirium, headache, convulsions, and/or [[hyperthermia]]. Fatal interactions have been reported including the death of [[Libby Zion]].<ref name=brody>{{cite news| vauthors = Brody J |author-link=Jane Brody|title=A Mix of Medicines That Can Be Lethal|url=https://www.nytimes.com/2007/02/27/health/27brody.html?n=Top/News/Health/Diseases,%20Conditions,%20and%20Health%20Topics/Antidepressants|work=[[New York Times]] |date=February 27, 2007 |access-date=2009-02-13 }}</ref> 

Seizures may develop when [[tramadol]] is given intravenously following, or with, pethidine.<ref>{{cite web|title=Serious Reactions with Tramadol: Seizures and Serotonin Syndrome|location=New Zealand Pharmacovigilance Centre, Dunedin|publisher=New Zealand Medicines and Medical Devices Safety Authority|website=medsafe.govt.nz|date=October 2007|access-date=7 November 2019|url=https://www.medsafe.govt.nz/profs/PUArticles/TramSerious.htm|edition=Prescriber Update 28(1)}}</ref> It can interact as well with [[selective serotonin reuptake inhibitors|SSRIs]] and other [[antidepressant]]s, antiparkinson agents, migraine therapy, [[amphetamines|stimulants]] and other agents causing [[serotonin syndrome]]. It is thought to be caused by an increase in cerebral serotonin concentrations. It is probable that pethidine can also interact with a number of other medications, including muscle relaxants, [[benzodiazepine]]s, and [[ethanol]].