Editing Platelet (section)

===Shape===

Circulating inactivated platelets are biconvex discoid (lens-shaped) structures,<ref>{{cite journal |vauthors=Jain NC |title=A scanning electron microscopic study of platelets of certain animal species |journal=Thrombosis et Diathesis Haemorrhagica |volume=33 |issue=3 |pages=501–7 |date=June 1975 |pmid=1154309}}</ref><ref name=Michelson>{{cite book |last1=Michelson |first1=Alan D. |title=Platelets |year=2013 |publisher=Academic |isbn=978-0-12-387837-3 |oclc=820818942  |edition=3rd}}</ref>{{rp|117–118}} 2–3&nbsp;μm in greatest diameter.<ref>{{cite journal |vauthors=Paulus JM |title=Platelet size in man |journal=Blood |volume=46 |issue=3 |pages=321–336 |date=September 1975 |pmid=1097000 |doi=10.1182/blood.V46.3.321.321 |doi-access=free}}</ref> Activated platelets have cell membrane projections covering their surface.

In a first approximation, the shape can be considered similar to [[spheroid#Oblate spheroids|oblate spheroids]], with a semiaxis ratio of 2 to 8.<ref>{{cite journal |vauthors=Frojmovic MM |title=Geometry of normal mammalian platelets by quantitative microscopic studies |journal=Biophysical Journal |volume=16 |issue=9 |pages=1071–89 |date=1976 |doi=10.1016/s0006-3495(76)85756-6 |pmid=786400 |pmc=1334946 |bibcode=1976BpJ....16.1071F}}</ref> This approximation can be used to model the hydrodynamic and optical properties of a population, as well as to restore the geometric parameters of individual measured platelets by [[flow cytometry]].<ref>{{cite journal |vauthors=Moskalensky AE, Yurkin MA, Konokhova AI, Strokotov DI, Nekrasov VM, Chernyshev AV, Tsvetovskaya GA, Chikova ED, Maltsev VP |title=Accurate measurement of volume and shape of resting and activated blood platelets from light scattering |journal=Journal of Biomedical Optics |date=2013 |volume=18 |issue=1 |pages=017001 |doi=10.1117/1.JBO.18.1.017001 |pmid=23288415 |bibcode=2013JBO....18a7001M |s2cid=44626047|doi-access=free }}</ref> More accurate biophysical models of platelet surface morphology that model its shape from first principles, make it possible to obtain a more realistic platelet geometry in a calm and activated state.<ref>{{cite journal |vauthors=Moskalensky AE, Yurkin MA, Muliukov AR, Litvinenko AL, Nekrasov VM, Chernyshev AV, Maltsev VP |title=Method for the simulation of blood platelet shape and its evolution during activation |journal=PLOS Computational Biology |volume=14 |issue=3 |pages=e1005899 |date=2018 |doi=10.1371/journal.pcbi.1005899 |pmid=29518073 |pmc=5860797 |bibcode=2018PLSCB..14E5899M |doi-access=free }}</ref>