Editing Precocious puberty (section)

=== Peripheral ===
Secondary sexual development induced by [[sex steroid]]s from other abnormal sources is referred to as ''peripheral precocious puberty'' or ''precocious pseudopuberty.'' It typically presents as a severe form of disease with children. Symptoms are usually as a sequelae from adrenal hyperplasia (because of [[Congenital adrenal hyperplasia due to 21-hydroxylase deficiency|21-hydroxylase deficiency]] or [[Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency|11-beta hydroxylase deficiency]], the former being more common), which includes but is not limited to hypertension, hypotension, electrolyte abnormalities, ambiguous genitalia in females, signs of virilization in females. Blood tests will typically reveal high level of [[androgen]]s with low levels of cortisol.

Causes can include:
* Endogenous sources
** [[Gonad]]al tumors (such as [[arrhenoblastoma]])
** [[Adrenal]] tumors
** [[Germ cell tumor]]<ref>{{Cite journal | last1 = Masse | first1 = R. J. | last2 = Shaw | first2 = P. J. | last3 = Burgess | first3 = M. | doi = 10.1111/j.1440-1754.1993.tb03022.x | title = Intracranial choriocarcinoma causing precocious puberty and cured with combined modality therapy | journal = Journal of Paediatrics and Child Health | volume = 29 | issue = 6 | pages = 464–467 | year = 2008 | pmid =  8286166| s2cid = 21886832 }}</ref><ref>{{Cite journal | doi = 10.2165/00148581-200406040-00002 | last1 = Antoniazzi | first1 = F. | last2 = Zamboni | first2 = G. | s2cid = 21330464 | title = Central precocious puberty: current treatment options | journal = Paediatric Drugs | volume = 6 | issue = 4 | pages = 211–231 | year = 2004 | pmid = 15339200}}</ref>
** [[Congenital adrenal hyperplasia]]
** [[McCune–Albright syndrome]]
** [[Silver–Russell syndrome]]
** [[Familial male-limited precocious puberty]] (testotoxicosis)
* Exogenous hormones
** [[Environmental exogenous hormones]]
** As treatment for another condition