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SH3 domain
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==SH3 interactomes== SH3 domain-mediated protein-protein interaction networks, ''i.e.'', SH3 interactomes, revealed that worm SH3 interactome resembles the analogous yeast network because it is significantly enriched for proteins with roles in endocytosis.<ref name=":0">{{Cite journal|last1=Xin|first1=Xiaofeng|last2=Gfeller|first2=David|last3=Cheng|first3=Jackie|last4=Tonikian|first4=Raffi|last5=Sun|first5=Lin|last6=Guo|first6=Ailan|last7=Lopez|first7=Lianet|last8=Pavlenco|first8=Alevtina|last9=Akintobi|first9=Adenrele|date=2013-01-01|title=SH3 interactome conserves general function over specific form|journal=Molecular Systems Biology|volume=9|pages=652|doi=10.1038/msb.2013.9|issn=1744-4292|pmc=3658277|pmid=23549480}}</ref><ref>{{Cite journal|last1=Tonikian|first1=Raffi|last2=Xin|first2=Xiaofeng|last3=Toret|first3=Christopher P.|last4=Gfeller|first4=David|last5=Landgraf|first5=Christiane|last6=Panni|first6=Simona|last7=Paoluzi|first7=Serena|last8=Castagnoli|first8=Luisa|last9=Currell|first9=Bridget|date=2009-10-01|title=Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins|journal=PLOS Biology|volume=7|issue=10|pages=e1000218|doi=10.1371/journal.pbio.1000218|issn=1545-7885|pmc=2756588|pmid=19841731 |doi-access=free }}</ref> Nevertheless, orthologous SH3 domain-mediated interactions are highly rewired between worm and yeast.<ref name=":0" />
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