Editing Semisynthesis (section)

== Notable examples in drug development ==
Practical applications of semisynthesis include the groundbreaking isolation of the antibiotic [[chlortetracycline]] and the subsequent semisynthesis of antibiotics such as [[tetracycline]], doxycycline, and [[tigecycline]].<ref name=Tetrahist>{{cite journal | vauthors = Nelson ML, Levy SB | title = The history of the tetracyclines | journal = Annals of the New York Academy of Sciences | volume = 1241 | issue = December | pages = 17–32 | date = December 2011 | pmid = 22191524 | doi = 10.1111/j.1749-6632.2011.06354.x | s2cid = 34647314 | bibcode = 2011NYASA1241...17N }}</ref><ref name=MyersPlatformHist>{{cite journal | vauthors = Liu F, Myers AG | title = Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics | journal = Current Opinion in Chemical Biology | volume = 32 | pages = 48–57 | date = June 2016 | pmid = 27043373 | doi = 10.1016/j.cbpa.2016.03.011 | doi-access = free }}</ref> Other notable examples include the early commercial production of the anti-cancer agent [[paclitaxel total synthesis|paclitaxel]] from 10-deacetylbaccatin, isolated from ''[[Taxus baccata]]'' (European yew),<ref name=Goodman>{{cite book| vauthors = Goodman J, Walsh V |title=The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug|url={{google books |plainurl=y |id=vHOOcw4buKoC}}|date=5 March 2001|publisher=Cambridge University Press|isbn=978-0-521-56123-5 | pages = 100f}}</ref> the semisynthesis of [[LSD]] from [[ergotamine]] (derived from fungal cultures of [[ergot]]),{{citation needed|date=March 2017}} and the preparation of the antimalarial drug [[artemether]] from the naturally occurring compound [[artemisinin]].<ref name=BoehmOPRD07>{{cite journal |vauthors=Boehm M, Fuenfschilling PC, Krieger M, Kuesters E, Struber F | date = 2007 | title = An Improved Manufacturing Process for the Antimalaria Drug Coartem. Part I | journal = Org. Process Res. Dev.| volume = 11 | issue = 3 | pages = 336–340 | doi=10.1021/op0602425}}</ref>{{primary source inline|date=March 2017}}{{primary source inline|date=March 2017}} As synthetic chemistry advances, transformations that were previously too costly or difficult to achieve become more feasible, influencing the economic viability of semisynthetic routes.<ref name="rsc.org"/>